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Tbio
SNF8
Vacuolar-sorting protein SNF8

Protein Summary
Description
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290330
  • ENSP00000290330
  • ENSG00000159210
  • ENST00000502492
  • ENSP00000421380

Symbol
  • EAP30
  • Dot3
  • EAP30
  • VPS22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
histone modification site profile
0.88
interacting protein
0.86
cellular component
0.81
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.16   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.16   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Endosomal Sorting Complex Required For Transport (ESCRT) (R-HSA-917729)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Endosomal Sorting Complex Required For Transport (ESCRT)
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
VPS36
Tbio
Novelty: 0.04226354
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VPS25
Tbio
Novelty: 0.05198234
p_int: 0.999999977
p_ni: 1.4e-8
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CHMP6
Tbio
Novelty: 0.0478065
Score: 0.997
Data Source: STRINGDB
VPS28
Tbio
Novelty: 0.04542177
Score: 0.995
Data Source: Reactome,STRINGDB
CHMP4B
Tbio
Novelty: 0.02197696
Score: 0.991
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00310287
Score: 0.989
Data Source: Reactome,STRINGDB
CHMP3
Tbio
Novelty: 0.02751272
Score: 0.986
Data Source: STRINGDB
CHMP2A
Tbio
Novelty: 0.00337804
Score: 0.984
Data Source: STRINGDB
CHMP4A
Tbio
Novelty: 0.01746823
Score: 0.984
Data Source: STRINGDB
HGS
Tbio
Family: Enzyme
Novelty: 0.00097717
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.16

PubMed score by year
PubTator Score  15.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer