SNF8
Vacuolar-sorting protein SNF8
Protein Summary
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins ...more
- ENST00000290330
- ENSP00000290330
- ENSG00000159210
- ENST00000502492
- ENSP00000421380
- EAP30
- Dot3
- EAP30
- VPS22
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.89 | ||
histone modification site profile | 0.88 | ||
interacting protein | 0.86 | ||
cellular component | 0.81 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.06 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.06 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (80)
VPS25
Novelty: 0.03002488
p_int: 0.999999977
p_ni: 1.4e-8
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Endosomal Sorting Complex Required For Transport (ESCRT) | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Endosomal Sorting Complex Required For Transport (ESCRT) | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (5)
Components (13)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 6 | 3 | 1.1 | 94.4 | |||||
body height | 3 | 3 | 3 | 83.6 | |||||
alkaline phosphatase measurement | 2 | 2 | 2 | 6.6 | 80 | ||||
body mass index | 1 | 1 | 1 | 75.1 | |||||
odontogenesis | 1 | 1 | 1 | 65.5 | |||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 1.1 | 94.4 | |||||
body height | 3 | 83.6 | |||||
alkaline phosphatase measurement | 2 | 6.6 | 80 | ||||
body mass index | 1 | 75.1 | |||||
odontogenesis | 1 | 65.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | SNF8, ESCRT-II complex subunit | 700029 | ||||||
Mouse | MGI:1343161 | 27681 | ||||||
Rat | RGD:1310144 | 287645 | ||||||
Dog | SNF8, ESCRT-II complex subunit | VGNC:46601 | 491063 | |||||
Horse | SNF8, ESCRT-II complex subunit | VGNC:23386 | 100055830 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | SNF8, ESCRT-II complex subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | SNF8, ESCRT-II complex subunit | |||||
Horse | SNF8, ESCRT-II complex subunit | |||||
Publication Statistics
PubMed Score 22.06
PubMed score by year
PubTator Score 15.40
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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