Tbio SNF8 Vacuolar-sorting protein SNF8

Protein Summary

Description

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q96H20
• Q8IXY3
• Q9UN50

Gene Name

• SNF8

Ensembl ID

• ENST00000290330
• ENSP00000290330
• ENSG00000159210
• ENST00000502492
• ENSP00000421380

Symbol

• EAP30
• Dot3
• EAP30
• VPS22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.89
histone modification site profile	0.88
interacting protein	0.86
cellular component	0.81
transcription factor perturbation	0.8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.16   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.16   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (4)

Reactome (3)

KEGG (1)

Endosomal Sorting Complex Required For Transport (ESCRT) (R-HSA-917729)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Endosomal Sorting Complex Required For Transport (ESCRT)	31 targets	R-HSA-917729
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Endosomal Sorting Complex Required For Transport (ESCRT)	31 targets	R-HSA-917729
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (33)

Functions (5)

Components (13)

Processes (15)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
channel regulator activity	Inferred from Direct Assay (IDA)	UniProtKB
transcription factor binding	Inferred from Direct Assay (IDA)	MGI
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB

Protein-Protein Interactions (80)

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1 – 10 of 80

• See Interactions on String-DB

VPS36

Tbio

Novelty: 0.04226354

p_int: 1

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

VPS25

Tbio

Novelty: 0.05198234

p_int: 0.999999977

p_ni: 1.4e-8

p_wrong: 9e-9

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

CHMP6

Tbio

Novelty: 0.0478065

Score: 0.997

Data Source: STRINGDB

VPS28

Tbio

Novelty: 0.04542177

Score: 0.995

Data Source: Reactome,STRINGDB

CHMP4B

Tbio

Novelty: 0.02197696

Score: 0.991

Data Source: STRINGDB

TSG101

Tbio

Novelty: 0.00310287

Score: 0.989

Data Source: Reactome,STRINGDB

CHMP3

Tbio

Novelty: 0.02751272

Score: 0.986

Data Source: STRINGDB

CHMP2A

Tbio

Novelty: 0.00337804

Score: 0.984

Data Source: STRINGDB

CHMP4A

Tbio

Novelty: 0.01746823

Score: 0.984

Data Source: STRINGDB

HGS

Tbio

Family: Enzyme

Novelty: 0.00097717

Score: 0.973

Data Source: STRINGDB

Publication Statistics

PubMed Score  22.16

PubMed score by year

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PubTator Score  15.4

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Coiled coil
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Protein transport

MGI Phenotype Find Similar Targets

homeostasis/metabolism phenotype
mortality/aging