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Tdark
SLC41A3
Solute carrier family 41 member 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315891
  • ENSP00000326070
  • ENSG00000114544
  • ENST00000346785
  • ENSP00000264471
  • ENST00000360370
  • ENSP00000353533
  • ENST00000383598
  • ENSP00000373092
  • ENST00000508835
  • ENSP00000427409

Symbol
  • SLC41A1-L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
cell type or tissue
0.72
transcription factor
0.67
tissue sample
0.65
small molecule perturbation
0.64


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
4
2
4
90.3
glomerular filtration rate
1
1
1
61.4
serum metabolite measurement
2
1
2
59.6
homocysteine measurement
1
1
1
56.4
serum alanine aminotransferase measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
4
90.3
glomerular filtration rate
1
61.4
serum metabolite measurement
2
59.6
homocysteine measurement
1
56.4
serum alanine aminotransferase measurement
1
38.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 41 member 3
VGNC:8005
460654
Macaque
solute carrier family 41 member 3
716921
Mouse
MGI:1918949
71699
Rat
RGD:1589573
641603
Dog
solute carrier family 41 member 3
VGNC:46414
606774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 41 member 3
Macaque
solute carrier family 41 member 3
Mouse
Rat
Dog
solute carrier family 41 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96GZ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (39)
1 – 10 of 39
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.999932622
p_ni:  0.000026952
p_wrong:  0.000040426
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.999931958
p_ni:  0.00003015
p_wrong:  0.000037892
Score:  0.189
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.975627744
p_ni:  0.022681411
p_wrong:  0.001690845
Data Source:  BioPlex
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.948171405
p_ni:  0.051828594
p_wrong:  2e-9
Score:  0.289
Data Source:  BioPlex,STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.910150348
p_ni:  0.015017178
p_wrong:  0.074832474
Data Source:  BioPlex
OR13J1
Tdark
Family:  oGPCR
Novelty:  2.15311005
p_int:  0.889975755
p_ni:  0.000614743
p_wrong:  0.109409502
Data Source:  BioPlex
NMUR2
Tchem
Family:  GPCR
Novelty:  0.01353039
p_int:  0.875629073
p_ni:  0.00003209
p_wrong:  0.124338837
Score:  0.187
Data Source:  BioPlex,STRINGDB
SLC12A9
Tdark
Family:  Transporter
Novelty:  0.12936696
p_int:  0.868296495
p_ni:  0.000595006
p_wrong:  0.131108499
Data Source:  BioPlex
SLC12A6
Tbio
Family:  Transporter
Novelty:  0.0132619
p_int:  0.863000989
p_ni:  0.028953993
p_wrong:  0.108045018
Data Source:  BioPlex
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.841819067
p_ni:  0.000014164
p_wrong:  0.158166769
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.43

PubMed score by year
PubTator Score  2.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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