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Tbio
APIP
Methylthioribulose-1-phosphate dehydratase

Protein Summary
Description
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395787
  • ENSP00000379133
  • ENSG00000149089

Symbol
  • APIP2
  • CGI29
  • hAPIP
  • CGI-29
  • MMRP19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor perturbation
0.8
cell type or tissue
0.68
disease perturbation
0.68
biological process
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.83   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.83   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
61.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
61.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1926788
56369
Rat
RGD:1564562
295961
Dog
APAF1 interacting protein
VGNC:37986
475943
Horse
APAF1 interacting protein [Source:HGNC Symbol;Acc:HGNC:17581]
Cow
APAF1 interacting protein
VGNC:26016
508345
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
APAF1 interacting protein
Horse
APAF1 interacting protein [Source:HGNC Symbol;Acc:HGNC:17581]
Cow
APAF1 interacting protein
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Cytochrome c-mediated apoptotic response
Reactome
Formation of apoptosome
Reactome
Intrinsic Pathway for Apoptosis
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Intrinsic Pathway for Apoptosis
Protein-Protein Interactions (54)
1 – 10 of 54
FASTKD2
Tbio
Family: Enzyme
Novelty: 0.12614412
p_int: 0.999946943
p_ni: 0.000053057
Score: 0.198
Data Source: BioPlex,STRINGDB
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.997626549
p_ni: 0.002373451
Score: 0.158
Data Source: BioPlex,STRINGDB
LYG2
Tbio
Family: Enzyme
Novelty: 0.12091256
p_int: 0.995592185
p_ni: 0.004407815
Score: 0.211
Data Source: BioPlex,STRINGDB
ISOC2
Tbio
Family: Enzyme
Novelty: 0.33841868
p_int: 0.916414523
p_ni: 0.083585477
Score: 0.158
Data Source: BioPlex,STRINGDB
HEPHL1
Tbio
Novelty: 0.44678065
p_int: 0.885536071
p_ni: 0.114458311
p_wrong: 0.000005618
Score: 0.189
Data Source: BioPlex,STRINGDB
UBA3
Tbio
Novelty: 0.03962261
p_int: 0.849199475
p_ni: 0.150800524
p_wrong: 1e-9
Score: 0.587
Data Source: BioPlex,STRINGDB
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.795124421
p_ni: 0.204874852
p_wrong: 7.27e-7
Data Source: BioPlex
ENOPH1
Tbio
Family: Enzyme
Novelty: 0.07679925
Score: 0.997
Data Source: STRINGDB
MRI1
Tbio
Family: Enzyme
Novelty: 0.01167103
Score: 0.986
Data Source: STRINGDB
ADI1
Tbio
Family: Enzyme
Novelty: 0.00908955
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.83

PubMed score by year
PubTator Score  8.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer