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Tbio
MASTL
Serine/threonine-protein kinase greatwall

Protein Classes
Protein Summary
Description
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342386
  • ENSP00000343446
  • ENSG00000120539
  • ENST00000375940
  • ENSP00000365107
  • ENST00000375946
  • ENSP00000365113

Symbol
  • GW
  • GWL
  • THC2
  • GW
  • GWL
  • THC2
  • MAST-L
  • GREATWALL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.88
virus perturbation
0.88
transcription factor binding site profile
0.69
tissue sample
0.65


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.75   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.75   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
1
2
73.7
platelet count
1
1
1
17.1
smoking initiation
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
73.7
platelet count
1
17.1
smoking initiation
1
4.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated serine/threonine kinase like
VGNC:4743
450367
Macaque
microtubule associated serine/threonine kinase like
708134
Mouse
MGI:1914371
67121
Dog
microtubule associated serine/threonine kinase like
VGNC:43036
607216
Horse
microtubule associated serine/threonine kinase like
VGNC:19992
100055294
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated serine/threonine kinase like
Macaque
microtubule associated serine/threonine kinase like
Mouse
Dog
microtubule associated serine/threonine kinase like
Horse
microtubule associated serine/threonine kinase like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96GX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
MASTL Facilitates Mitotic Progression
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
M Phase
MASTL Facilitates Mitotic Progression
Mitotic Prophase
Protein-Protein Interactions (89)
1 – 10 of 89
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999983
p_ni:  1.7e-8
Data Source:  BioPlex
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.999999896
p_wrong:  1.04e-7
Score:  0.319
Data Source:  BioPlex,STRINGDB
ARPP19
Tbio
Novelty:  0.03109958
Score:  0.996
Data Source:  Reactome,STRINGDB
ENSA
Tbio
Novelty:  0.01642444
Score:  0.996
Data Source:  Reactome,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
Score:  0.983
Data Source:  STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.983
Data Source:  Reactome,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.961
Data Source:  Reactome,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.948
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.947
Data Source:  STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  98.75

PubMed score by year
PubTator Score  43.8

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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