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Tbio
BCAN
Brevican core protein

Protein Summary
Description
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329117
  • ENSP00000331210
  • ENSG00000132692
  • ENST00000361588
  • ENSP00000354925

Symbol
  • BEHAB
  • CSPG7
  • BEHAB
  • CSPG7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
pathway
0.67
PubMedID
0.67
cellular component
0.66
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
VCAN
Tbio
Novelty:  0.00110986
p_int:  0.99999445
p_ni:  0.000005493
p_wrong:  5.7e-8
Score:  0.972
Data Source:  BioPlex,STRINGDB
ULK3
Tchem
Family:  Kinase
Novelty:  0.0783598
p_int:  0.99997977
p_ni:  3.5e-8
p_wrong:  0.000020195
Score:  0.622
Data Source:  BioPlex,STRINGDB
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.98083866
p_ni:  0.019155339
p_wrong:  0.000006002
Score:  0.234
Data Source:  BioPlex,STRINGDB
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
Score:  0.976
Data Source:  STRINGDB
CSPG4
Tbio
Novelty:  0.0038499
Score:  0.967
Data Source:  STRINGDB
CSPG5
Tbio
Novelty:  0.01629685
Score:  0.963
Data Source:  STRINGDB
DCN
Tbio
Novelty:  0.00073027
Score:  0.956
Data Source:  STRINGDB
ADAMTS5
Tchem
Family:  Enzyme
Novelty:  0.00364004
Score:  0.956
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.955
Data Source:  STRINGDB
CHPF
Tbio
Family:  Enzyme
Novelty:  0.02590604
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
3
3
84.7
neuroimaging measurement
10
1
10
46.3
leukocyte count
2
1
2
33.4
neutrophil count
1
1
1
28.9
total blood protein measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
84.7
neuroimaging measurement
10
46.3
leukocyte count
2
33.4
neutrophil count
1
28.9
total blood protein measurement
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
brevican
VGNC:455
457401
Macaque
brevican
718545
Mouse
MGI:1096385
12032
Rat
RGD:2194
25393
Dog
brevican
VGNC:38395
612102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
brevican
Macaque
brevican
Mouse
Rat
Dog
brevican
Publication Statistics
PubMed Score 181.05
PubMed score by year
PubTator Score 20.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title