Tbio ABHD17A Alpha/beta hydrolase domain-containing protein 17A

Protein Summary

Description

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity).

Uniprot Accession IDs

• Q96GS6
• A8K0G8
• D6W5Z9
• Q6PJU2
• Q8WUH9
• Q9BWL0
• Q9H7Q9
• Abhydrolase domain-containing protein 17A

Gene Name

• ABHD17A

Ensembl ID

• ENST00000250974
• ENSP00000250974
• ENSG00000129968
• ENST00000292577
• ENSP00000292577

Symbol

• C19orf27
• FAM108A1
• C19orf27
• FAM108A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
kinase perturbation	0.71
cell line	0.62
transcription factor	0.62
tissue sample	0.61

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Alpha/beta Hydrolase Domain-containing Protein 17a

Protein / ... / Cysteine Protease / Alpha/beta Hydrolase Domain-containing Protein 17a

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Protein Abhd17a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0