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Tbio
ACSBG1
Long-chain-fatty-acid--CoA ligase ACSBG1

Protein Summary
Description
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258873
  • ENSP00000258873
  • ENSG00000103740

Symbol
  • BGM
  • KIAA0631
  • LPD
  • BG
  • BG1
  • BGM
  • LPD
  • GR-LACS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
kinase perturbation
0.76
trait
0.61
cell line
0.54
pathway
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
NOL11
Tbio
Novelty:  0.47253767
p_int:  0.999866301
p_ni:  0.000133699
Data Source:  BioPlex
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.942
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.937
Data Source:  STRINGDB
ACADL
Tbio
Family:  Enzyme
Novelty:  0.0298212
Score:  0.927
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.92
Data Source:  STRINGDB
FADS2
Tbio
Family:  Enzyme
Novelty:  0.00180901
Score:  0.916
Data Source:  STRINGDB
ELOVL6
Tchem
Novelty:  0.00817818
Score:  0.915
Data Source:  STRINGDB
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
Score:  0.904
Data Source:  STRINGDB
ELOVL1
Tbio
Novelty:  0.03178348
Score:  0.904
Data Source:  STRINGDB
ABCD2
Tbio
Family:  Transporter
Novelty:  0.01352365
Score:  0.9
Data Source:  STRINGDB
Pathways (20)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
7
8
99.4
reticulocyte count
4
5
8
95.7
reticulocyte measurement
2
4
6
92.2
hematocrit
3
4
4
90.5
hemoglobin measurement
2
2
2
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
8
99.4
reticulocyte count
8
95.7
reticulocyte measurement
6
92.2
hematocrit
4
90.5
hemoglobin measurement
2
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase bubblegum family member 1
VGNC:11784
453566
Macaque
acyl-CoA synthetase bubblegum family member 1
709676
Mouse
MGI:2385656
94180
Rat
RGD:708557
171410
Dog
acyl-CoA synthetase bubblegum family member 1
VGNC:37529
479067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase bubblegum family member 1
Macaque
acyl-CoA synthetase bubblegum family member 1
Mouse
Rat
Dog
acyl-CoA synthetase bubblegum family member 1
Publication Statistics
PubMed Score 259.84
PubMed score by year
PubTator Score 194.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title