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Tbio
CDCA7L
Cell division cycle-associated 7-like protein

Protein Summary
Description
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356195
  • ENSP00000348523
  • ENSG00000164649
  • ENST00000373934
  • ENSP00000363045
  • ENST00000406877
  • ENSP00000383986

Symbol
  • HR1
  • JPO2
  • R1
  • R1
  • JPO2
  • RAM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.71
transcription factor perturbation
0.61
cell type or tissue
0.6
histone modification site profile
0.58
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.997066591
p_ni:  1.02e-7
p_wrong:  0.002933306
Score:  0.477
Data Source:  BioPlex,STRINGDB
POGZ
Tbio
Novelty:  0.03603188
Score:  0.805
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.79
Data Source:  STRINGDB
RAPGEF5
Tbio
Novelty:  0.02449802
Score:  0.755
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.747
Data Source:  STRINGDB
PSIP1
Tchem
Family:  Epigenetic
Novelty:  0.00216601
Score:  0.727
Data Source:  STRINGDB
MARK4
Tchem
Family:  Kinase
Novelty:  0.01908376
Score:  0.626
Data Source:  STRINGDB
TMEM196
Tdark
Novelty:  0.37594264
Score:  0.593
Data Source:  STRINGDB
DNAH11
Tbio
Novelty:  0.02448234
Score:  0.593
Data Source:  STRINGDB
SP4
Tbio
Family:  TF
Novelty:  0.02444442
Score:  0.591
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (77)
Find Similar Targets
Items per page:
1 – 5 of 77
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Signaling of Hepatocyte Growth Factor Receptor
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Signaling of Hepatocyte Growth Factor Receptor
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
69.8
2
1
0
1.4
61
myeloid white cell count
1
1
1
42.3
AL amyloidosis
1
1
0
1.4
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
69.8
0
1.4
61
myeloid white cell count
1
42.3
AL amyloidosis
0
1.4
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 7 like
VGNC:7361
472306
Macaque
cell division cycle associated 7 like
711948
Mouse
MGI:2384982
217946
Rat
RGD:1564080
619566
Dog
cell division cycle associated 7 like
VGNC:39016
482347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 7 like
Macaque
cell division cycle associated 7 like
Mouse
Rat
Dog
cell division cycle associated 7 like
Publication Statistics
PubMed Score 23.69
PubMed score by year
PubTator Score 22.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title