Tbio CDCA7L Cell division cycle-associated 7-like protein

Protein Summary

Description

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Uniprot Accession IDs

• Q96GN5
• A4D141
• A6NF50
• B3KTR5
• B4DUT3
• C9K0Y1
• Q6PIL4
• Q86YT0
• Q8IXN5
• Q96C70
• Q9H9A2
• Q9NPV2

Gene Name

• CDCA7L

Ensembl ID

• ENST00000356195
• ENSP00000348523
• ENSG00000164649
• ENST00000373934
• ENSP00000363045
• ENST00000406877
• ENSP00000383986

Symbol

• HR1
• JPO2
• R1
• R1
• JPO2
• RAM2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.71
transcription factor perturbation	0.61
cell type or tissue	0.6
histone modification site profile	0.58
cell line	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.21   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.21   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0