Tbio TOE1 Target of EGR1 protein 1

Protein Summary

Description

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).

Uniprot Accession IDs

• Q96GM8
• B4DEM6
• Q6IA35
• Q8IWN5
• Q9H846

Gene Name

• TOE1

Ensembl ID

• ENST00000372090
• ENSP00000361162
• ENSG00000132773

Symbol

• PCH7
• hCaf1z

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
disease perturbation	0.79
transcription factor binding site profile	0.68
tissue sample	0.62
histone modification site profile	0.61

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Target Of Egr1 Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Target Of Egr1 Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.06   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.06   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0