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Tbio
SMARCD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381513
  • ENSP00000370924
  • ENSG00000066117
  • ENST00000394963
  • ENSP00000378414

Symbol
  • BAF60A
  • Rsc6p
  • BAF60A
  • CRACD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
protein complex
0.85
transcription factor binding site profile
0.85
disease perturbation
0.79
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Protein-Protein Interactions (147)
1 – 10 of 147
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.04842565
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.09141321
p_int: 1
Score: 0.985
Data Source: BioPlex,STRINGDB
DPF2
Tbio
Family: Epigenetic
Novelty: 0.01184879
p_int: 1
Score: 0.945
Data Source: BioPlex,STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.02547452
p_int: 0.999999936
p_ni: 6.4e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.55480559
p_int: 0.999999848
p_ni: 1.52e-7
Score: 0.898
Data Source: BioPlex,STRINGDB
BICRA
Tbio
Novelty: 0.21142986
p_int: 0.999999785
p_ni: 2.14e-7
p_wrong: 2e-9
Score: 0.722
Data Source: BioPlex,STRINGDB
BRD7
Tchem
Family: Epigenetic
Novelty: 0.02016653
p_int: 0.999999697
p_ni: 3.03e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
BRD9
Tchem
Family: Epigenetic
Novelty: 0.02324917
p_int: 0.999999579
p_ni: 4.2e-7
p_wrong: 1e-9
Score: 0.901
Data Source: BioPlex,STRINGDB
DPF1
Tbio
Family: Epigenetic
Novelty: 0.10224521
p_int: 0.999998801
p_ni: 0.000001195
p_wrong: 5e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
ARID1B
Tbio
Family: TF
Novelty: 0.01077178
p_int: 0.999998691
p_ni: 0.000001308
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.75

PubMed score by year
PubTator Score  16.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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