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Tbio
SMARCD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381513
  • ENSP00000370924
  • ENSG00000066117
  • ENST00000394963
  • ENSP00000378414

Symbol
  • BAF60A
  • Rsc6p
  • BAF60A
  • CRACD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
protein complex
0.85
transcription factor binding site profile
0.85
disease perturbation
0.79
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  1
Score:  0.985
Data Source:  BioPlex,STRINGDB
DPF2
Tbio
Family:  Epigenetic
Novelty:  0.0403366
p_int:  1
Score:  0.945
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999999848
p_ni:  1.52e-7
Score:  0.898
Data Source:  BioPlex,STRINGDB
BICRA
Tbio
Novelty:  0.13482404
p_int:  0.999999785
p_ni:  2.14e-7
p_wrong:  2e-9
Score:  0.722
Data Source:  BioPlex,STRINGDB
BRD7
Tchem
Family:  Epigenetic
Novelty:  0.01820848
p_int:  0.999999697
p_ni:  3.03e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
BRD9
Tchem
Family:  Epigenetic
Novelty:  0.03450227
p_int:  0.999999579
p_ni:  4.2e-7
p_wrong:  1e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
DPF1
Tbio
Family:  Epigenetic
Novelty:  0.0713809
p_int:  0.999998801
p_ni:  0.000001195
p_wrong:  5e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
ARID1B
Tbio
Family:  TF
Novelty:  0.00731933
p_int:  0.999998691
p_ni:  0.000001308
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
75.1
diastolic blood pressure
1
1
1
70.8
BMI-adjusted hip circumference
2
2
2
55.8
comparative body size at age 10, self-reported
1
1
1
50.6
2
1
0
6.2
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
75.1
diastolic blood pressure
1
70.8
BMI-adjusted hip circumference
2
55.8
comparative body size at age 10, self-reported
1
50.6
0
6.2
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
VGNC:10373
451889
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
712130
Mouse
MGI:1933623
83797
Rat
RGD:1305406
363002
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
VGNC:46537
486548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Publication Statistics
PubMed Score 31.90
PubMed score by year
PubTator Score 16.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title