Tdark PLPPR2 Phospholipid phosphatase-related protein type 2

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pyrophosphatase / Phospholipid Phosphatase-related Protein Type 2

Protein / Hydrolase / Phosphatase / Phospholipid Phosphatase-related Protein Type 2

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Phospholipid Phosphatase-related Protein Type 2

Protein Summary

Uniprot Accession IDs

• Q96GM1
• Q5CZ76
• Q8N1U4
• Q9H929

Gene Name

• PLPPR2

Ensembl ID

• ENST00000251473
• ENSP00000251473
• ENSG00000105520
• ENST00000591608
• ENSP00000466898

Symbol

• LPPR2
• PRG4
• PRG4
• LPPR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1	1	1		21.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1		21.4

Reset Zoom  Beta Count   Odds Ratio

Pathways (6)

Reactome (5)

PathwayCommons (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Lysosphingolipid and LPA receptors	14 targets	R-HSA-419408
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
GPCR ligand binding	460 targets	R-HSA-500792
Lysosphingolipid and LPA receptors	14 targets	R-HSA-419408
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Gene Ontology Terms (6)

Functions (3)

Components (1)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
lipid phosphatase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidate phosphatase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (52)

Explore Interacting Targets

1 – 10 of 52

• See Interactions on String-DB

C9orf40

Tdark

Novelty: 2.72763898

p_int: 0.999932539

p_ni: 0.000067458

p_wrong: 3e-9

Score: 0.189

Data Source: BioPlex,STRINGDB

DPP9

Tchem

Family: Enzyme

Novelty: 0.00976924

p_int: 0.997569996

p_ni: 0.002430003

Data Source: BioPlex

ISCA1

Tbio

Novelty: 0.01288069

p_int: 0.99714293

p_ni: 0.00285705

p_wrong: 2e-8

Data Source: BioPlex

TTC5

Tbio

Novelty: 0.12127698

p_int: 0.992453771

p_ni: 0.007546229

Data Source: BioPlex

DNAJC12

Tbio

Novelty: 0.05214775

p_int: 0.989049221

p_ni: 0.010950779

Data Source: BioPlex

EPN1

Tbio

Novelty: 0.01788784

p_int: 0.989005207

p_ni: 0.010994729

p_wrong: 6.4e-8

Score: 0.198

Data Source: BioPlex,STRINGDB

YTHDF1

Tbio

Novelty: 0.02063275

p_int: 0.983499656

p_ni: 0.016500344

Data Source: BioPlex

METAP1

Tchem

Family: Enzyme

Novelty: 0.01816253

p_int: 0.983109264

p_ni: 0.016890736

Score: 0.161

Data Source: BioPlex,STRINGDB

SEC24D

Tbio

Novelty: 0.04795527

p_int: 0.971423947

p_ni: 0.028236365

p_wrong: 0.000339688

Score: 0.218

Data Source: BioPlex,STRINGDB

METAP2

Tchem

Family: Enzyme

Novelty: 0.00570955

p_int: 0.956756419

p_ni: 0.043243581

Data Source: BioPlex

Publication Statistics

PubMed Score  1.04

PubMed score by year

Reset Zoom

PubTator Score  0.59

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

platelet count