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Tdark
PLPPR2
Phospholipid phosphatase-related protein type 2

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
21.4
Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Lysosphingolipid and LPA receptors
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (52)
1 – 10 of 52
C9orf40
Tdark
Novelty: 2.72763898
p_int: 0.999932539
p_ni: 0.000067458
p_wrong: 3e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
DPP9
Tchem
Family: Enzyme
Novelty: 0.00976924
p_int: 0.997569996
p_ni: 0.002430003
Data Source: BioPlex
ISCA1
Tbio
Novelty: 0.01288069
p_int: 0.99714293
p_ni: 0.00285705
p_wrong: 2e-8
Data Source: BioPlex
TTC5
Tbio
Novelty: 0.12127698
p_int: 0.992453771
p_ni: 0.007546229
Data Source: BioPlex
DNAJC12
Tbio
Novelty: 0.05214775
p_int: 0.989049221
p_ni: 0.010950779
Data Source: BioPlex
EPN1
Tbio
Novelty: 0.01788784
p_int: 0.989005207
p_ni: 0.010994729
p_wrong: 6.4e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
YTHDF1
Tbio
Novelty: 0.02063275
p_int: 0.983499656
p_ni: 0.016500344
Data Source: BioPlex
METAP1
Tchem
Family: Enzyme
Novelty: 0.01816253
p_int: 0.983109264
p_ni: 0.016890736
Score: 0.161
Data Source: BioPlex,STRINGDB
SEC24D
Tbio
Novelty: 0.04795527
p_int: 0.971423947
p_ni: 0.028236365
p_wrong: 0.000339688
Score: 0.218
Data Source: BioPlex,STRINGDB
METAP2
Tchem
Family: Enzyme
Novelty: 0.00570955
p_int: 0.956756419
p_ni: 0.043243581
Data Source: BioPlex
Publication Statistics
PubMed Score  1.04

PubMed score by year
PubTator Score  0.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer