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Tbio
TRMT2B
tRNA (uracil(54)-C(5))-methyltransferase homolog

Protein Summary
Description
Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity). This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372935
  • ENSP00000362026
  • ENSG00000188917
  • ENST00000372936
  • ENSP00000362027
  • ENST00000372939
  • ENSP00000362030
  • ENST00000545398
  • ENSP00000438134

Symbol
  • CXorf34
  • CXorf34
  • dJ341D10.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
cell type or tissue
0.75
tissue sample
0.67
transcription factor perturbation
0.61
virus perturbation
0.59


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.48   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.48   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 2 homolog B
VGNC:1189
465756
Macaque
tRNA methyltransferase 2 homolog B
702087
Mouse
MGI:2442530
215201
Horse
tRNA methyltransferase 2 homolog B
VGNC:24540
100057429
Platypus
tRNA methyltransferase 2 homolog B [Source:HGNC Symbol;Acc:HGNC:25748]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 2 homolog B
Macaque
tRNA methyltransferase 2 homolog B
Mouse
Horse
tRNA methyltransferase 2 homolog B
Platypus
tRNA methyltransferase 2 homolog B [Source:HGNC Symbol;Acc:HGNC:25748]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96GJ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (134)
1 – 10 of 134
PPTC7
Tdark
Family:  Enzyme
Novelty:  0.36770849
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.999999137
p_ni:  8.63e-7
Data Source:  BioPlex
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.999761684
p_ni:  0.000238313
p_wrong:  3e-9
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999444979
p_ni:  0.000554918
p_wrong:  1.03e-7
Score:  0.264
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999424605
p_ni:  0.000575371
p_wrong:  2.4e-8
Score:  0.3
Data Source:  BioPlex,STRINGDB
NELL1
Tbio
Family:  Enzyme
Novelty:  0.01325888
p_int:  0.998928492
p_ni:  0.001071508
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.994635598
p_ni:  0.005362556
p_wrong:  0.000001846
Score:  0.162
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.99429895
p_ni:  0.005687336
p_wrong:  0.000013713
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.985026044
p_ni:  0.014962532
p_wrong:  0.000011424
Data Source:  BioPlex
EIF5A2
Tbio
Novelty:  0.01527502
p_int:  0.878169574
p_ni:  0.038236415
p_wrong:  0.083594011
Data Source:  BioPlex
Publication Statistics
PubMed Score  7.48

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer