Protein Summary
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
- ENST00000292782
- ENSP00000292782
- ENSG00000043093
- DCN1
- DCUN1L1
- RP42
- SCCRO
- RP42
- SCRO
- Tes3
- DCNL1
- SCCRO
- DCUN1L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.88 | ||
histone modification site profile | 0.81 | ||
kinase perturbation | 0.66 | ||
tissue sample | 0.66 | ||
cell line | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.91 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 258 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.91 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 258 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 91
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (91)
Protein-Protein Interactions (215)
UBE2M
Novelty: 0.02353106
p_int: 0.99999941
p_ni: 2.9e-8
p_wrong: 5.61e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SPANXN4
Novelty: 1.91062423
p_int: 0.999606117
p_ni: 0.000043003
p_wrong: 0.000350881
Data Source: BioPlex
CUL3
Novelty: 0.0028737
p_int: 0.998618232
p_ni: 0.000009597
p_wrong: 0.001372171
Score: 0.991
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Neddylation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Neddylation | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 5 | 1 | 1.2 | 94.5 | |||||
blood metabolite measurement | 1 | 1 | 1 | 67.1 | |||||
lymphocyte count | 2 | 2 | 2 | 59.4 | |||||
reticulocyte measurement | 1 | 1 | 1 | 53.3 | |||||
reticulocyte count | 2 | 2 | 2 | 50.4 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.2 | 94.5 | |||||
blood metabolite measurement | 1 | 67.1 | |||||
lymphocyte count | 2 | 59.4 | |||||
reticulocyte measurement | 1 | 53.3 | |||||
reticulocyte count | 2 | 50.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | defective in cullin neddylation 1 domain containing 1 | VGNC:11380 | 460870 | |||||
Macaque | defective in cullin neddylation 1 domain containing 1 | 708357 | ||||||
Mouse | MGI:2150386 | 114893 | ||||||
Dog | defective in cullin neddylation 1 domain containing 1 | VGNC:39822 | 606979 | |||||
Horse | defective in cullin neddylation 1 domain containing 1 | VGNC:17062 | 100066587 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | defective in cullin neddylation 1 domain containing 1 | |||||
Macaque | defective in cullin neddylation 1 domain containing 1 | |||||
Mouse | ||||||
Dog | defective in cullin neddylation 1 domain containing 1 | |||||
Horse | defective in cullin neddylation 1 domain containing 1 | |||||
Publication Statistics
PubMed Score 42.91
PubMed score by year
PubTator Score 26.36
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (16)
Items per page:
0 of 0
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