Tbio DCUN1D1 DCN1-like protein 1

Protein Summary

Description

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Uniprot Accession IDs

• Q96GG9
• B2RB37
• Q7L3G9
• Q8TEX7
• Q9H6M1
• Q9HCT3

Gene Name

• DCUN1D1

Ensembl ID

• ENST00000292782
• ENSP00000292782
• ENSG00000043093

Symbol

• DCN1
• DCUN1L1
• RP42
• SCCRO
• RP42
• SCRO
• Tes3
• DCNL1
• SCCRO
• DCUN1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.81
kinase perturbation	0.66
tissue sample	0.66
cell line	0.56

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.21   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.21   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	1	1		55.4
Parkinson's disease	EFO_0002508	1	1	0	1.2	7

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1		55.4
Parkinson's disease	EFO_0002508	0	1.2	7

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	defective in cullin neddylation 1 domain containing 1	VGNC:11380	460870
Macaque	defective in cullin neddylation 1 domain containing 1		708357
Mouse	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	MGI:2150386	114893
Dog	defective in cullin neddylation 1 domain containing 1	VGNC:39822	606979
Horse	defective in cullin neddylation 1 domain containing 1	VGNC:17062	100066587

Species	Name	OMA	EggNOG	Inparanoid
Chimp	defective in cullin neddylation 1 domain containing 1
Macaque	defective in cullin neddylation 1 domain containing 1
Mouse	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Dog	defective in cullin neddylation 1 domain containing 1
Horse	defective in cullin neddylation 1 domain containing 1

Protein Data Bank (10)

1 – 5 of 10

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Neddylation	234 targets	R-HSA-8951664
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Neddylation	234 targets	R-HSA-8951664
Post-translational protein modification	1450 targets	R-HSA-597592

Gene Ontology Terms (10)

Functions (3)

Components (3)

Processes (4)

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10

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GO Term	Evidence	Assigned by
cullin family protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin conjugating enzyme binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin-like protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (215)

Explore Interacting Targets

1 – 10 of 215

• See Interactions on String-DB

UBE2M

Tbio

Novelty: 0.02353106

p_int: 0.99999941

p_ni: 2.9e-8

p_wrong: 5.61e-7

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

SPANXN4

Tdark

Novelty: 1.91062423

p_int: 0.999606117

p_ni: 0.000043003

p_wrong: 0.000350881

Data Source: BioPlex

CUL3

Tbio

Novelty: 0.0028737

p_int: 0.998618232

p_ni: 0.000009597

p_wrong: 0.001372171

Score: 0.991

Data Source: BioPlex,STRINGDB

NEDD8

Tbio

Novelty: 0.00305343

Score: 0.999

Data Source: Reactome,STRINGDB

CUL1

Tbio

Novelty: 0.00244476

Score: 0.999

Data Source: Reactome,STRINGDB

RBX1

Tbio

Family: Enzyme

Novelty: 0.00596986

Score: 0.999

Data Source: Reactome,STRINGDB

UBE2F

Tbio

Novelty: 0.06951245

Score: 0.989

Data Source: Reactome,STRINGDB

RNF7

Tbio

Novelty: 0.02532658

Score: 0.984

Data Source: STRINGDB

CAND1

Tbio

Novelty: 0.0196525

Score: 0.983

Data Source: STRINGDB

CUL5

Tbio

Novelty: 0.00792494

Score: 0.981

Data Source: STRINGDB

Publication Statistics

PubMed Score  40.21

PubMed score by year

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PubTator Score  26.36

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Complete proteome
Nucleus
Proto-oncogene
Reference proteome
Ubl conjugation pathway

GWAS Trait Find Similar Targets

heel bone mineral density
Parkinson's disease

MGI Phenotype Find Similar Targets

cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
reproductive system phenotype