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Tchem
DCUN1D1
DCN1-like protein 1

Protein Summary
Description
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292782
  • ENSP00000292782
  • ENSG00000043093

Symbol
  • DCN1
  • DCUN1L1
  • RP42
  • SCCRO
  • RP42
  • SCRO
  • Tes3
  • DCNL1
  • SCCRO
  • DCUN1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.81
kinase perturbation
0.66
tissue sample
0.66
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.91   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.91   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 91
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (215)
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.99999941
p_ni:  2.9e-8
p_wrong:  5.61e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999606117
p_ni:  0.000043003
p_wrong:  0.000350881
Data Source:  BioPlex
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.998618232
p_ni:  0.000009597
p_wrong:  0.001372171
Score:  0.991
Data Source:  BioPlex,STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.999
Data Source:  Reactome,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.999
Data Source:  Reactome,STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.999
Data Source:  Reactome,STRINGDB
UBE2F
Tbio
Novelty:  0.06951245
Score:  0.989
Data Source:  Reactome,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.984
Data Source:  STRINGDB
CAND1
Tbio
Novelty:  0.0196525
Score:  0.983
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
1
1.2
94.5
blood metabolite measurement
1
1
1
67.1
lymphocyte count
2
2
2
59.4
reticulocyte measurement
1
1
1
53.3
reticulocyte count
2
2
2
50.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
94.5
blood metabolite measurement
1
67.1
lymphocyte count
2
59.4
reticulocyte measurement
1
53.3
reticulocyte count
2
50.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defective in cullin neddylation 1 domain containing 1
VGNC:11380
460870
Macaque
defective in cullin neddylation 1 domain containing 1
708357
Mouse
MGI:2150386
114893
Dog
defective in cullin neddylation 1 domain containing 1
VGNC:39822
606979
Horse
defective in cullin neddylation 1 domain containing 1
VGNC:17062
100066587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defective in cullin neddylation 1 domain containing 1
Macaque
defective in cullin neddylation 1 domain containing 1
Mouse
Dog
defective in cullin neddylation 1 domain containing 1
Horse
defective in cullin neddylation 1 domain containing 1
Publication Statistics
PubMed Score 42.91
PubMed score by year
PubTator Score 26.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title