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Tbio
RNF185
E3 ubiquitin-protein ligase RNF185

Protein Summary
Description
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266252
  • ENSP00000266252
  • ENSG00000138942
  • ENST00000326132
  • ENSP00000320508
  • ENST00000518626
  • ENSP00000427755
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
transcription factor binding site profile
0.71
cellular component
0.68
tissue sample
0.64
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
92.5
eosinophil percentage of granulocytes
1
1
1
68.6
eosinophil percentage of leukocytes
1
1
1
67.3
neutrophil percentage of granulocytes
1
1
1
63.1
vitamin D measurement
3
1
3
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
92.5
eosinophil percentage of granulocytes
1
68.6
eosinophil percentage of leukocytes
1
67.3
neutrophil percentage of granulocytes
1
63.1
vitamin D measurement
3
55.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 185
VGNC:6157
458768
Macaque
ring finger protein 185
718351
Mouse
MGI:1922078
193670
Rat
RGD:1564777
360967
Dog
ring finger protein 185
VGNC:45648
486362
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 185
Macaque
ring finger protein 185
Mouse
Rat
Dog
ring finger protein 185
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96GF1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective CFTR causes cystic fibrosis
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective CFTR causes cystic fibrosis
Protein-Protein Interactions (72)
1 – 10 of 72
COA1
Tbio
Family:  Enzyme
Novelty:  0.49194068
p_int:  0.998591414
p_ni:  0.001408534
p_wrong:  5.2e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.991667964
p_ni:  0.008332036
Score:  0.175
Data Source:  BioPlex,STRINGDB
TMEM259
Tbio
Novelty:  0.10015777
p_int:  0.98978283
p_ni:  0.01021717
Score:  0.188
Data Source:  BioPlex,STRINGDB
ST7L
Tbio
Novelty:  0.03661324
p_int:  0.974796857
p_ni:  0.024642613
p_wrong:  0.00056053
Score:  0.175
Data Source:  BioPlex,STRINGDB
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.972404838
p_ni:  0.027595162
Score:  0.167
Data Source:  BioPlex,STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.964746605
p_ni:  0.035253395
Score:  0.186
Data Source:  BioPlex,STRINGDB
TMBIM6
Tbio
Novelty:  0.00151958
p_int:  0.860949479
p_ni:  0.139050521
Score:  0.236
Data Source:  BioPlex,STRINGDB
RHBDD1
Tbio
Family:  Enzyme
Novelty:  0.10354568
p_int:  0.751814222
p_ni:  0.008557373
p_wrong:  0.239628405
Score:  0.315
Data Source:  BioPlex,STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.953
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.946
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.95

PubMed score by year
PubTator Score  2.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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