You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
CALML4
Calmodulin-like protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395465
  • ENSP00000378848
  • ENSG00000129007
  • ENST00000448060
  • ENSP00000400755
  • ENST00000467889
  • ENSP00000419081
  • ENST00000540479
  • ENSP00000438177

Symbol
  • NY-BR-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.8
microRNA
0.78
disease perturbation
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
32.2
eosinophil count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
32.2
eosinophil count
1
30.2
Pathways (44)
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Inflammatory mediator regulation of TRP channels
KEGG
Aldosterone synthesis and secretion
KEGG
Oxytocin signaling pathway
KEGG
Kaposi sarcoma-associated herpesvirus infection
KEGG
Gastric acid secretion
Name
Explore in Pharos
Explore in Source
Inflammatory mediator regulation of TRP channels
Aldosterone synthesis and secretion
Oxytocin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Gastric acid secretion
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (116)
1 – 10 of 116
CAMKK2
Tchem
Family: Kinase
Novelty: 0.00426898
Score: 0.893
Data Source: STRINGDB
CAMK4
Tbio
Family: Kinase
Novelty: 0.00412444
Score: 0.886
Data Source: STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.869
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.855
Data Source: STRINGDB
NOS1
Tchem
Family: Enzyme
Novelty: 0.00032064
Score: 0.855
Data Source: STRINGDB
PHKA2
Tbio
Family: Kinase
Novelty: 0.00461145
Score: 0.838
Data Source: STRINGDB
PHKB
Tbio
Family: Enzyme
Novelty: 0.05506418
Score: 0.834
Data Source: STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
Score: 0.834
Data Source: STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.834
Data Source: STRINGDB
PHKG1
Tchem
Family: Kinase
Novelty: 0.08576384
Score: 0.827
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.63

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer