You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
AURKB
Aurora kinase B

Protein Summary
Description
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316199
  • ENSP00000313950
  • ENSG00000178999
  • ENST00000534871
  • ENSP00000443869
  • ENST00000578549
  • ENSP00000462207
  • ENST00000585124
  • ENSP00000463999

Symbol
  • AIK2
  • AIM1
  • AIRK2
  • ARK2
  • STK1
  • STK12
  • STK5
  • AIK2
  • AIM1
  • ARK2
  • AurB
  • IPL1
  • STK5
  • AIM-1
  • ARK-2
  • STK-1
  • STK12
  • PPP1R48
  • aurkb-sv1
  • aurkb-sv2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
gene perturbation
0.99
biological process
0.98
molecular function
0.96
chemical bioactivity profile
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 822   (req: < 5)
Gene RIFs: 280   (req: <= 3)
Antibodies: 993   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 822   (req: >= 5)
Gene RIFs: 280   (req: > 3)
Antibodies: 993   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 619
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
axitinib
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (55)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Gene Ontology Terms (48)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (581)
1 – 10 of 581
HSP90AA4P
Tdark
p_int: 0.999836597
p_ni: 0.000163398
p_wrong: 5e-9
Data Source: BioPlex
RBM12B
Tdark
Novelty: 7.74193548
p_int: 0.999684635
p_ni: 0.000002697
p_wrong: 0.000312667
Score: 0.722
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.998756097
p_ni: 0.001243903
Data Source: BioPlex
SUGT1
Tbio
Novelty: 0.17606795
p_int: 0.960758497
p_ni: 0.039241503
Score: 0.28
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00020424
p_int: 0.939700931
p_ni: 0.060299069
Score: 0.492
Data Source: BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty: 0.01466977
p_int: 0.877998508
p_ni: 0.122001492
Score: 0.296
Data Source: BioPlex,STRINGDB
CCNB2
Tbio
Novelty: 0.01021878
Score: 0.999
Data Source: STRINGDB
NDC80
Tbio
Novelty: 0.00334097
Score: 0.999
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00237728
Score: 0.999
Data Source: STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.0040442
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  822.00

PubMed score by year
PubTator Score  657.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: