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Tbio
VMP1
Vacuole membrane protein 1

Protein Classes
Protein Summary
Description
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494). This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262291
  • ENSP00000262291
  • ENSG00000062716

Symbol
  • TDC1
  • TMEM49
  • EPG3
  • TANGO5
  • TMEM49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
small molecule perturbation
0.96
transcription factor binding site profile
0.9
histone modification site profile
0.84
cell type or tissue
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.96   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.96   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
93.4
myeloid white cell count
2
2
2
90.7
neutrophil count
3
2
3
89.5
hemoglobin measurement
3
3
3
75.3
leukocyte count
2
2
2
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
93.4
myeloid white cell count
2
90.7
neutrophil count
3
89.5
hemoglobin measurement
3
75.3
leukocyte count
2
72.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vacuole membrane protein 1
VGNC:9778
455171
Mouse
MGI:1923159
75909
Rat
RGD:70367
192129
Dog
vacuole membrane protein 1
VGNC:49873
111097413
Horse
vacuole membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:29559]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vacuole membrane protein 1
Mouse
Rat
Dog
vacuole membrane protein 1
Horse
vacuole membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:29559]
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (63)
1 – 10 of 63
DPEP1
Tclin
Family: Enzyme
Novelty: 0.00384946
p_int: 0.999299204
p_ni: 0.000700796
Score: 0.177
Data Source: BioPlex,STRINGDB
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.945435214
p_ni: 0.054438409
p_wrong: 0.000126377
Data Source: BioPlex
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.02794035
p_int: 0.923811057
p_ni: 0.075852487
p_wrong: 0.000336456
Data Source: BioPlex
CDH13
Tbio
Novelty: 0.00389516
p_int: 0.902940937
p_ni: 0.097059063
Score: 0.248
Data Source: BioPlex,STRINGDB
KLRC4
Tbio
Novelty: 0.16922525
p_int: 0.891044724
p_ni: 0.10886996
p_wrong: 0.000085315
Data Source: BioPlex
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.80939204
p_ni: 0.190578044
p_wrong: 0.000029916
Score: 0.186
Data Source: BioPlex,STRINGDB
MICB
Tbio
Novelty: 0.00364639
p_int: 0.800849845
p_ni: 0.199033057
p_wrong: 0.000117098
Data Source: BioPlex
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.800849845
p_ni: 0.199033057
p_wrong: 0.000117098
Data Source: BioPlex
BECN1
Tbio
Novelty: 0.0003792
Score: 0.977
Data Source: STRINGDB
ATG13
Tbio
Novelty: 0.00951471
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.96

PubMed score by year
PubTator Score  36.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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