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Tbio
ZNF274
Neurotrophin receptor-interacting factor homolog

Protein Summary
Description
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345813
  • ENSP00000321187
  • ENSG00000171606
  • ENST00000424679
  • ENSP00000409872
  • ENST00000610905
  • ENSP00000478533
  • ENST00000617501
  • ENSP00000484810

Symbol
  • ZKSCAN19
  • ZF2
  • HFB101
  • ZSCAN51
  • ZKSCAN19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.98
histone modification site profile
0.94
protein domain
0.92
transcription factor binding site profile
0.92


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 274
VGNC:2183
456343
Macaque
zinc finger protein 274
712237
Mouse
MGI:2176229
170936
Rat
RGD:1306339
308362
Horse
zinc finger protein 274 [Source:HGNC Symbol;Acc:HGNC:13068]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 274
Macaque
zinc finger protein 274
Mouse
Rat
Horse
zinc finger protein 274 [Source:HGNC Symbol;Acc:HGNC:13068]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96GC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
p_int: 0.999997858
p_ni: 0.000002142
Score: 0.981
Data Source: BioPlex,STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
p_int: 0.999979214
p_ni: 0.000020786
Score: 0.22
Data Source: BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.999429795
p_ni: 0.0005702
p_wrong: 5e-9
Data Source: BioPlex
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.943644026
p_ni: 0.056355974
Data Source: BioPlex
MRPL27
Tbio
Novelty: 0.15636105
p_int: 0.894796959
p_ni: 0.105203041
Score: 0.175
Data Source: BioPlex,STRINGDB
MRPS14
Tdark
Novelty: 0.37802685
p_int: 0.794355711
p_ni: 0.205644289
Score: 0.163
Data Source: BioPlex,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
p_int: 0.769120194
p_ni: 0.230641157
p_wrong: 0.000238649
Score: 0.194
Data Source: BioPlex,STRINGDB
MALSU1
Tbio
Novelty: 0.38026342
p_int: 0.756094525
p_ni: 0.09491796
p_wrong: 0.148987515
Data Source: BioPlex
NGFR
Tclin
Novelty: 0.00072052
Score: 0.96
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.48

PubMed score by year
PubTator Score  27.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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