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Tdark
MRPL48
39S ribosomal protein L48, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310614
  • ENSP00000308717
  • ENSG00000175581

Symbol
  • L48MT
  • CGI-118
  • HSPC290
  • MRP-L48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.92
kinase perturbation
0.88
interacting protein
0.83
transcription factor binding site profile
0.79


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.46   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.46   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L48
VGNC:3106
451414
Macaque
mitochondrial ribosomal protein L48
718240
Mouse
MGI:1289321
52443
Rat
RGD:1307576
293149
Dog
mitochondrial ribosomal protein L48
476812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L48
Macaque
mitochondrial ribosomal protein L48
Mouse
Rat
Dog
mitochondrial ribosomal protein L48
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96GC5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (137)
1 – 10 of 137
MRPL46
Tdark
Novelty: 0.6199259
p_int: 0.999129837
p_ni: 0.000870163
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.998194659
p_ni: 0.001805341
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.998070052
p_ni: 0.001929948
Score: 0.979
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.998031476
p_ni: 0.001968524
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.996396739
p_ni: 0.003603261
Score: 0.989
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.994364168
p_ni: 0.005635832
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.993711732
p_ni: 0.006288268
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.991700323
p_ni: 0.008299676
p_wrong: 1e-9
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.990344848
p_ni: 0.009655151
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPL41
Tbio
Novelty: 0.04024303
p_int: 0.975287736
p_ni: 0.024712264
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.46

PubMed score by year
PubTator Score  2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer