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Tbio
SDSL
Serine dehydratase-like

Protein Summary
Description
Has low serine dehydratase and threonine dehydratase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345635
  • ENSP00000341117
  • ENSG00000139410
  • ENST00000403593
  • ENSP00000385790

Symbol
  • TDH
  • cSDH
  • SDH 2
  • SDS-RS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
cell line
0.51
cell type or tissue
0.51
pathway
0.51
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.79   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.79   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.952
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.937
Data Source:  STRINGDB
PSPH
Tbio
Family:  Enzyme
Novelty:  0.01078634
Score:  0.934
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.927
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.925
Data Source:  STRINGDB
SRR
Tbio
Family:  Enzyme
Novelty:  0.00425993
Score:  0.925
Data Source:  STRINGDB
CBSL
Tdark
Novelty:  0.00062189
Score:  0.923
Data Source:  STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.913
Data Source:  STRINGDB
BCKDHA
Tbio
Family:  Enzyme
Novelty:  0.01684893
Score:  0.909
Data Source:  STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (76)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Threonine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Threonine catabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
49.2
self reported educational attainment
1
1
1
31.4
cognitive function measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
49.2
self reported educational attainment
1
31.4
cognitive function measurement
1
1.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine dehydratase like
VGNC:8531
452275
Macaque
serine dehydratase like
714721
Mouse
MGI:2182607
257635
Rat
RGD:1309192
360816
Dog
serine dehydratase like
VGNC:45959
486282
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine dehydratase like
Macaque
serine dehydratase like
Mouse
Rat
Dog
serine dehydratase like
Publication Statistics
PubMed Score 47.79
PubMed score by year
PubTator Score 61.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title