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Tchem
P2RY11
P2Y purinoceptor 11

Protein Summary
Description
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321826
  • ENSP00000323872
  • ENSG00000244165

Symbol
  • P2Y11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.68
tissue sample
0.62
cellular component
0.61
ligand (chemical)
0.59
cell type or tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.26   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.26   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (278)
1 – 10 of 278
ADORA2B
Tclin
Family: GPCR
Novelty: 0.00096284
Score: 0.953
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00034048
Score: 0.939
Data Source: STRINGDB
P2RY6
Tchem
Family: GPCR
Novelty: 0.00676114
Score: 0.929
Data Source: STRINGDB
P2RY2
Tclin
Family: GPCR
Novelty: 0.00220741
Score: 0.929
Data Source: STRINGDB
PPAN
Tbio
Novelty: 0.01063709
Score: 0.922
Data Source: STRINGDB
P2RY1
Tchem
Family: GPCR
Novelty: 0.00203299
Score: 0.918
Data Source: STRINGDB
P2RY10
Tchem
Family: GPCR
Novelty: 0.12674578
Score: 0.916
Data Source: STRINGDB
HCRTR2
Tclin
Family: GPCR
Novelty: 0.00960861
Score: 0.916
Data Source: STRINGDB
LPAR6
Tchem
Family: GPCR
Novelty: 0.01801122
Score: 0.915
Data Source: STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.26

PubMed score by year
PubTator Score  55.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer