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Tbio
OTUD5
OTU domain-containing protein 5

Protein Summary
Description
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000156084
  • ENSP00000156084
  • ENSG00000068308
  • ENST00000376488
  • ENSP00000365671
  • ENST00000396743
  • ENSP00000379969
  • ENST00000428668
  • ENSP00000401629

Symbol
  • DUBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.73
microRNA
0.66
tissue
0.65
virus perturbation
0.59


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase 5
VGNC:1513
737927
Macaque
OTU deubiquitinase 5
711927
Mouse
MGI:1859615
54644
Rat
RGD:1563027
363452
Dog
OTU deubiquitinase 5
VGNC:44187
480911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase 5
Macaque
OTU deubiquitinase 5
Mouse
Rat
Dog
OTU deubiquitinase 5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
Immune System
Innate Immune System
Metabolism of proteins
Protein-Protein Interactions (71)
1 – 10 of 71
TNFAIP3
Tbio
Novelty: 0.00257088
p_int: 0.999997466
p_ni: 0.000001892
p_wrong: 6.42e-7
Score: 0.556
Data Source: BioPlex,STRINGDB
TRIM35
Tbio
Novelty: 0.03280419
p_int: 0.999901788
p_ni: 0.000020986
p_wrong: 0.000077227
Score: 0.204
Data Source: BioPlex,STRINGDB
RABGEF1
Tbio
Novelty: 0.02830695
p_int: 0.999751668
p_ni: 0.000056063
p_wrong: 0.000192269
Score: 0.265
Data Source: BioPlex,STRINGDB
GRN
Tbio
Novelty: 0.00096395
p_int: 0.999733208
p_ni: 0.000014938
p_wrong: 0.000251854
Score: 0.303
Data Source: BioPlex,STRINGDB
PIF1
Tbio
Family: Enzyme
Novelty: 0.00449506
p_int: 0.796706993
p_ni: 0.00005542
p_wrong: 0.203237587
Data Source: BioPlex
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.995
Data Source: Reactome,STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.95
Data Source: Reactome,STRINGDB
TRIM25
Tbio
Family: Enzyme
Novelty: 0.0045864
Score: 0.948
Data Source: Reactome,STRINGDB
MAVS
Tbio
Novelty: 0.00241215
Score: 0.945
Data Source: Reactome,STRINGDB
RNF135
Tbio
Family: Enzyme
Novelty: 0.05600338
Score: 0.944
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  20.78

PubMed score by year
PubTator Score  8.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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