Tbio OTUD5 OTU domain-containing protein 5

Protein Summary

Description

Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q96G74
• B4DGG7
• G5E9D7
• Q4KMN9
• Q8N6T5
• Q9H650
• Q9H9U0
• Q9NT65

Gene Name

• OTUD5

Ensembl ID

• ENST00000156084
• ENSP00000156084
• ENSG00000068308
• ENST00000376488
• ENSP00000365671
• ENST00000396743
• ENSP00000379969
• ENST00000428668
• ENSP00000401629

Symbol

• DUBA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
transcription factor binding site profile	0.73
microRNA	0.66
tissue	0.65
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Otu Domain-containing Protein 5

Protein / Hydrolase / Protease / Cysteine Protease / Otu Domain-containing Protein 5

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Otu Domain-containing Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.21   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.21   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0