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Tbio
OTUD5
OTU domain-containing protein 5

Protein Summary
Description
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000156084
  • ENSP00000156084
  • ENSG00000068308
  • ENST00000376488
  • ENSP00000365671
  • ENST00000396743
  • ENSP00000379969
  • ENST00000428668
  • ENSP00000401629

Symbol
  • DUBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.73
microRNA
0.66
tissue
0.65
virus perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.51   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.51   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
59.8
eosinophil percentage of leukocytes
1
1
1
56.2
1
1
0
1.1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
59.8
eosinophil percentage of leukocytes
1
56.2
0
1.1
2.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase 5
VGNC:1513
737927
Macaque
OTU deubiquitinase 5
711927
Mouse
MGI:1859615
54644
Rat
RGD:1563027
363452
Dog
OTU deubiquitinase 5
VGNC:44187
480911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase 5
Macaque
OTU deubiquitinase 5
Mouse
Rat
Dog
OTU deubiquitinase 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96G74-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
Immune System
Innate Immune System
Metabolism of proteins
Protein-Protein Interactions (71)
1 – 10 of 71
TNFAIP3
Tbio
Novelty:  0.00257088
p_int:  0.999997466
p_ni:  0.000001892
p_wrong:  6.42e-7
Score:  0.556
Data Source:  BioPlex,STRINGDB
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.999901788
p_ni:  0.000020986
p_wrong:  0.000077227
Score:  0.204
Data Source:  BioPlex,STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.999751668
p_ni:  0.000056063
p_wrong:  0.000192269
Score:  0.265
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.999733208
p_ni:  0.000014938
p_wrong:  0.000251854
Score:  0.303
Data Source:  BioPlex,STRINGDB
PIF1
Tbio
Family:  Enzyme
Novelty:  0.00449506
p_int:  0.796706993
p_ni:  0.00005542
p_wrong:  0.203237587
Data Source:  BioPlex
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.995
Data Source:  Reactome,STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.95
Data Source:  Reactome,STRINGDB
TRIM25
Tbio
Family:  Enzyme
Novelty:  0.0045864
Score:  0.948
Data Source:  Reactome,STRINGDB
MAVS
Tbio
Novelty:  0.00241215
Score:  0.945
Data Source:  Reactome,STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
Score:  0.944
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  21.51

PubMed score by year
PubTator Score  8.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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