You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MED8
Mediator of RNA polymerase II transcription subunit 8

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins. This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290663
  • ENSP00000290663
  • ENSG00000159479
  • ENST00000372455
  • ENSP00000361533
  • ENST00000372457
  • ENSP00000361535

Symbol
  • ARC32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
interacting protein
0.75
disease perturbation
0.74
transcription factor perturbation
0.74
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.99999996
p_ni:  3.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.99999983
p_ni:  1.7e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999999745
p_ni:  2.55e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999999742
p_ni:  1.96e-7
p_wrong:  6.2e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.999998553
p_ni:  0.000001447
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.99999798
p_ni:  0.000001887
p_wrong:  1.33e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999997621
p_ni:  0.000002379
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999987641
p_ni:  0.000012358
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  0.999980936
p_ni:  0.000019064
Score:  0.988
Data Source:  BioPlex,STRINGDB
MED7
Tbio
Family:  Enzyme
Novelty:  0.04773947
p_int:  0.999980042
p_ni:  0.000019958
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
4
4
92.3
platelet crit
2
3
4
88.5
systolic blood pressure
1
1
1
71.9
cognitive function measurement
3
2
3
48.4
asparaginase-induced acute pancreatitis
1
1
0
4.6
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
92.3
platelet crit
4
88.5
systolic blood pressure
1
71.9
cognitive function measurement
3
48.4
asparaginase-induced acute pancreatitis
0
4.6
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 8
VGNC:10715
100615212
Macaque
mediator complex subunit 8
700676
Mouse
MGI:1915269
80509
Horse
mediator complex subunit 8
VGNC:20091
100053257
Cow
mediator complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:19971]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 8
Macaque
mediator complex subunit 8
Mouse
Horse
mediator complex subunit 8
Cow
mediator complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:19971]
Publication Statistics
PubMed Score 16.73
PubMed score by year
PubTator Score 7.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title