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Tdark
IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

Protein Summary
Description
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259239
  • ENSP00000259239
  • ENSG00000136718

Symbol
  • BXDC4
  • BXDC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.88
histone modification site profile
0.81
kinase perturbation
0.81
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (341)
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.999717952
p_ni:  0.000282015
p_wrong:  3.3e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DIEXF
Tbio
Novelty:  0.05892659
p_int:  0.998637541
p_ni:  0.001362459
Score:  0.995
Data Source:  BioPlex,STRINGDB
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.961245124
p_ni:  0.038300465
p_wrong:  0.000454411
Score:  0.248
Data Source:  BioPlex,STRINGDB
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.922776396
p_ni:  0.077222354
p_wrong:  0.00000125
Score:  0.201
Data Source:  BioPlex,STRINGDB
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.911819881
p_ni:  0.088172657
p_wrong:  0.000007463
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.90673708
p_ni:  0.093261571
p_wrong:  0.000001349
Score:  0.464
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.895065125
p_ni:  0.104801464
p_wrong:  0.00013341
Score:  0.639
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.890119294
p_ni:  0.109878556
p_wrong:  0.00000215
Score:  0.95
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.8556453
p_ni:  0.144353106
p_wrong:  0.000001594
Score:  0.748
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.8549534
p_ni:  0.14504654
p_wrong:  6e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IMP4, U3 small nucleolar ribonucleoprotein
VGNC:1974
459604
Macaque
IMP4, U3 small nucleolar ribonucleoprotein
702144
Mouse
MGI:106572
27993
Rat
RGD:1308463
316317
Dog
IMP4, U3 small nucleolar ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:30856]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IMP4, U3 small nucleolar ribonucleoprotein
Macaque
IMP4, U3 small nucleolar ribonucleoprotein
Mouse
Rat
Dog
IMP4, U3 small nucleolar ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:30856]
Publication Statistics
PubMed Score 0.16
PubMed score by year
PubTator Score 21.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title