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Tbio
BICD1
Protein bicaudal D homolog 1

Protein Summary
Description
Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281474
  • ENSP00000281474
  • ENSG00000151746
  • ENST00000548411
  • ENSP00000446793
  • ENST00000551848
  • ENSP00000448933

Symbol
  • BICD
  • bic-D 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.84
histone modification site profile
0.82
biological process
0.79
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.45   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.45   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
63.6
Pathways (5)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (31)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (93)
1 – 10 of 93
BICD2
Tbio
Novelty: 0.01725046
p_int: 1
Score: 0.903
Data Source: BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty: 1.7921497
p_int: 0.999999999
p_ni: 1e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
SYBU
Tbio
Novelty: 0.06029092
p_int: 0.999998293
p_ni: 0.000001707
Score: 0.247
Data Source: BioPlex,STRINGDB
NEFL
Tbio
Novelty: 0.00049255
p_int: 0.998638849
p_ni: 0.000321349
p_wrong: 0.001039802
Score: 0.199
Data Source: BioPlex,STRINGDB
RAB6A
Tbio
Family: Enzyme
Novelty: 0.00546034
Score: 0.986
Data Source: Reactome,STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.975
Data Source: Reactome,STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.972
Data Source: Reactome,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.967
Data Source: Reactome,STRINGDB
DYNC1H1
Tbio
Novelty: 0.0098543
Score: 0.965
Data Source: Reactome,STRINGDB
DYNC1I1
Tbio
Novelty: 0.12175372
Score: 0.953
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  50.45

PubMed score by year
PubTator Score  21.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer