You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CHMP6
Charged multivesicular body protein 6

Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325167
  • ENSP00000317468
  • ENSG00000176108

Symbol
  • VPS20
  • VPS20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
cellular component
0.73
interacting protein
0.72
histone modification site profile
0.69
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (108)
1 – 10 of 108
RIPPLY1
Tdark
Novelty: 0.14203585
p_int: 0.917266662
p_ni: 0.082626915
p_wrong: 0.000106423
Score: 0.379
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01877097
p_int: 0.755130058
p_ni: 0.244850385
p_wrong: 0.000019557
Score: 0.259
Data Source: BioPlex,STRINGDB
VPS25
Tbio
Novelty: 0.05198234
Score: 0.999
Data Source: STRINGDB
VPS4A
Tbio
Novelty: 0.01985299
Score: 0.999
Data Source: STRINGDB
VPS36
Tbio
Novelty: 0.04226354
Score: 0.998
Data Source: STRINGDB
SNF8
Tbio
Novelty: 0.0473195
Score: 0.997
Data Source: STRINGDB
CHMP3
Tbio
Novelty: 0.02751272
Score: 0.996
Data Source: STRINGDB
CHMP2A
Tbio
Novelty: 0.00337804
Score: 0.996
Data Source: STRINGDB
VPS28
Tbio
Novelty: 0.04542177
Score: 0.994
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00310287
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.30

PubMed score by year
PubTator Score  13.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer