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Tbio
HMCES
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

Protein Summary
Description
Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383463
  • ENSP00000372955
  • ENSG00000183624
  • ENST00000389735
  • ENSP00000374385
  • ENST00000502878
  • ENSP00000426215

Symbol
  • C3orf37
  • DC12
  • SRAPD1
  • DC12
  • SRAPD1
  • C3orf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.9
gene perturbation
0.83
tissue sample
0.7
PubMedID
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
RPA2
Tbio
Novelty: 0.01534532
p_int: 0.999480085
p_ni: 0.000519915
Score: 0.241
Data Source: BioPlex,STRINGDB
RPA4
Tbio
Novelty: 0.04651163
p_int: 0.999426016
p_ni: 0.000573984
Score: 0.261
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00100906
p_int: 0.998654343
p_ni: 0.001345657
Data Source: BioPlex
KLHDC3
Tdark
Novelty: 0.27149321
p_int: 0.997242283
p_ni: 0.002744428
p_wrong: 0.000013289
Score: 0.156
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.04654771
p_int: 0.995210555
p_ni: 0.00376158
p_wrong: 0.001027865
Data Source: BioPlex
LAMTOR5
Tbio
Novelty: 0.00523099
p_int: 0.977605591
p_ni: 0.022388063
p_wrong: 0.000006347
Data Source: BioPlex
ARL2BP
Tbio
Novelty: 0.08238566
p_int: 0.883324405
p_ni: 0.092739012
p_wrong: 0.023936583
Data Source: BioPlex
HSPBP1
Tbio
Novelty: 0.01599246
p_int: 0.776863786
p_ni: 0.223136214
Score: 0.512
Data Source: BioPlex,STRINGDB
PRAG1
Tbio
Family: Kinase
Novelty: 0.00292989
Score: 0.87
Data Source: STRINGDB
TMA16
Tdark
Novelty: 3.33333333
Score: 0.723
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.39

PubMed score by year
PubTator Score  5.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer