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Tbio
PERP
p53 apoptosis effector related to PMP-22

Protein Summary
Description
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421351
  • ENSP00000397157
  • ENSG00000112378

Symbol
  • KCP1
  • KRTCAP1
  • PIGPC1
  • THW
  • THW
  • KCP1
  • PIGPC1
  • KRTCAP1
  • dJ496H19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.91
virus perturbation
0.83
histone modification site profile
0.79
transcription factor binding site profile
0.74


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.47   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.47   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PERP, TP53 apoptosis effector
VGNC:12689
463027
Macaque
PERP, TP53 apoptosis effector
703890
Mouse
MGI:1929938
64058
Rat
RGD:1310294
292949
Dog
PERP, TP53 apoptosis effector
VGNC:44424
476218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PERP, TP53 apoptosis effector
Macaque
PERP, TP53 apoptosis effector
Mouse
Rat
Dog
PERP, TP53 apoptosis effector
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96FX8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (72)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Gene expression (Transcription)
Generic Transcription Pathway
Keratinization
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (60)
1 – 10 of 60
TP63
Tbio
Family:  TF
Novelty:  0.00336108
Score:  0.977
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.967
Data Source:  STRINGDB
DSP
Tbio
Novelty:  0.00178018
Score:  0.965
Data Source:  STRINGDB
PKP3
Tbio
Novelty:  0.0269462
Score:  0.961
Data Source:  STRINGDB
DSG2
Tbio
Novelty:  0.00524156
Score:  0.95
Data Source:  STRINGDB
DSC3
Tbio
Novelty:  0.00457331
Score:  0.95
Data Source:  STRINGDB
PKP1
Tbio
Novelty:  0.0100609
Score:  0.95
Data Source:  STRINGDB
DSC2
Tbio
Novelty:  0.00642576
Score:  0.946
Data Source:  STRINGDB
PKP2
Tbio
Novelty:  0.00493803
Score:  0.943
Data Source:  STRINGDB
DSG1
Tbio
Novelty:  0.00142889
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  138.47

PubMed score by year
PubTator Score  27.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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