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Tbio
TRMT61A
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Protein Summary
Description
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389749
  • ENSP00000374399
  • ENSG00000166166

Symbol
  • C14orf172
  • TRM61
  • GCD14
  • TRM61
  • Gcd14p
  • hTRM61
  • C14orf172
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
virus perturbation
0.76
histone modification site profile
0.75
cell type or tissue
0.72
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
3
3
95.6
reticulocyte count
4
3
4
91.4
intelligence
7
9
3
6
82.3
serum gamma-glutamyl transferase measurement
1
1
1
77.3
7
4
2
1.1
77
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
95.6
reticulocyte count
4
91.4
intelligence
3
6
82.3
serum gamma-glutamyl transferase measurement
1
77.3
2
1.1
77
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 61A
VGNC:12394
453186
Macaque
tRNA methyltransferase 61A
695566
Mouse
MGI:2443487
328162
Rat
Dog
tRNA methyltransferase 61A
VGNC:47860
490871
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 61A
Macaque
tRNA methyltransferase 61A
Mouse
Rat
Dog
tRNA methyltransferase 61A
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96FX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (182)
1 – 10 of 182
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
p_int:  0.999999992
p_ni:  4e-9
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EVL
Tbio
Novelty:  0.03533257
p_int:  0.999999879
p_ni:  1.13e-7
p_wrong:  8e-9
Score:  0.263
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.999999756
p_ni:  2.44e-7
Score:  0.313
Data Source:  BioPlex,STRINGDB
ARHGEF12
Tchem
Novelty:  0.01365866
p_int:  0.999999375
p_ni:  6.25e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
SRP9
Tbio
Novelty:  0.02243103
p_int:  0.999998951
p_ni:  0.00000102
p_wrong:  2.9e-8
Score:  0.663
Data Source:  BioPlex,STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
p_int:  0.999932557
p_ni:  0.000067442
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.98455944
p_ni:  0.000055862
p_wrong:  0.015384698
Data Source:  BioPlex
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.983408822
p_ni:  0.000171652
p_wrong:  0.016419526
Score:  0.158
Data Source:  BioPlex,STRINGDB
PBLD
Tbio
Novelty:  0.09777309
p_int:  0.916384784
p_ni:  0.083615215
Score:  0.299
Data Source:  BioPlex,STRINGDB
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.850860468
p_ni:  0.140354297
p_wrong:  0.008785235
Score:  0.163
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.87

PubMed score by year
PubTator Score  5.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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