TRMT61A
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Protein Summary
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).
- ENST00000389749
- ENSP00000374399
- ENSG00000166166
- C14orf172
- TRM61
- GCD14
- TRM61
- Gcd14p
- hTRM61
- C14orf172
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.93 | ||
virus perturbation | 0.76 | ||
histone modification site profile | 0.75 | ||
cell type or tissue | 0.72 | ||
transcription factor binding site profile | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.92 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 65 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.92 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 65 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0