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Tdark
DPH3
DPH3 homolog

Protein Summary
Description
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383775
  • ENSP00000373285
  • ENSG00000154813
  • ENST00000488423
  • ENSP00000419599

Symbol
  • DESR1
  • ZCSL2
  • DESR1
  • DPH3A
  • KTI11
  • ZCSL2
  • DELGIP
  • DELGIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
kinase perturbation
0.76
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of diphthamide-EEF2
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Synthesis of diphthamide-EEF2
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (48)
1 – 10 of 48
SERGEF
Tdark
Novelty: 0.55408971
p_int: 0.999999994
p_ni: 6e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
DPH2
Tbio
Novelty: 0.09916185
p_int: 0.999972588
p_ni: 0.000027409
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
ATE1
Tbio
Family: Enzyme
Novelty: 0.0119888
p_int: 0.995621669
p_ni: 0.004378331
Score: 0.189
Data Source: BioPlex,STRINGDB
NEK7
Tchem
Family: Kinase
Novelty: 0.03876863
p_int: 0.836939113
p_ni: 0.076238122
p_wrong: 0.086822765
Score: 0.243
Data Source: BioPlex,STRINGDB
DPH1
Tbio
Novelty: 0.02897945
Score: 0.996
Data Source: Reactome,STRINGDB
EEF2
Tchem
Novelty: 0.00094881
Score: 0.984
Data Source: STRINGDB
DPH5
Tbio
Family: Enzyme
Novelty: 0.16551724
Score: 0.923
Data Source: STRINGDB
DPH7
Tbio
Family: Enzyme
Novelty: 0.12121212
Score: 0.895
Data Source: STRINGDB
ELP3
Tbio
Family: Epigenetic
Novelty: 0.01612945
Score: 0.88
Data Source: STRINGDB
DPH6
Tbio
Family: Enzyme
Novelty: 0.30009681
Score: 0.872
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.12

PubMed score by year
PubTator Score  5.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer