Tdark DPH3 DPH3 homolog

Protein Summary

Description

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q96FX2

Gene Name

• DPH3

Ensembl ID

• ENST00000383775
• ENSP00000373285
• ENSG00000154813
• ENST00000488423
• ENSP00000419599

Symbol

• DESR1
• ZCSL2
• DESR1
• DPH3A
• KTI11
• ZCSL2
• DELGIP
• DELGIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
transcription factor binding site profile	0.84
transcription factor perturbation	0.84
kinase perturbation	0.76
virus perturbation	0.72

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (5)

Reactome (4)

UniProt (1)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Synthesis of diphthamide-EEF2	8 targets	R-HSA-5358493

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Synthesis of diphthamide-EEF2	8 targets	R-HSA-5358493

Gene Ontology Terms (9)

Functions (1)

Components (4)

Processes (4)

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10

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GO Term	Evidence	Assigned by
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (48)

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1 – 10 of 48

• See Interactions on String-DB

SERGEF

Tdark

Novelty: 0.55408971

p_int: 0.999999994

p_ni: 6e-9

Score: 0.978

Data Source: BioPlex,STRINGDB

DPH2

Tbio

Novelty: 0.09916185

p_int: 0.999972588

p_ni: 0.000027409

p_wrong: 2e-9

Score: 0.997

Data Source: BioPlex,Reactome,STRINGDB

ATE1

Tbio

Family: Enzyme

Novelty: 0.0119888

p_int: 0.995621669

p_ni: 0.004378331

Score: 0.189

Data Source: BioPlex,STRINGDB

NEK7

Tchem

Family: Kinase

Novelty: 0.03876863

p_int: 0.836939113

p_ni: 0.076238122

p_wrong: 0.086822765

Score: 0.243

Data Source: BioPlex,STRINGDB

DPH1

Tbio

Novelty: 0.02897945

Score: 0.996

Data Source: Reactome,STRINGDB

EEF2

Tchem

Novelty: 0.00094881

Score: 0.984

Data Source: STRINGDB

DPH5

Tbio

Family: Enzyme

Novelty: 0.16551724

Score: 0.923

Data Source: STRINGDB

DPH7

Tbio

Family: Enzyme

Novelty: 0.12121212

Score: 0.895

Data Source: STRINGDB

ELP3

Tbio

Family: Epigenetic

Novelty: 0.01612945

Score: 0.88

Data Source: STRINGDB

DPH6

Tbio

Family: Enzyme

Novelty: 0.30009681

Score: 0.872

Data Source: STRINGDB

Publication Statistics

PubMed Score  19.12

PubMed score by year

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PubTator Score  5.57

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Reference proteome
Zinc
Zinc-finger

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
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