You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OTUB1
Ubiquitin thioesterase OTUB1

Protein Summary
Description
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. Plays a ke ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428192
  • ENSP00000402551
  • ENSG00000167770
  • ENST00000538426
  • ENSP00000444357

Symbol
  • OTB1
  • OTU1
  • OTB1
  • OTU1
  • HSPC263
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
co-expressed gene
0.82
transcription factor binding site profile
0.77
biological process
0.68
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.92   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.92   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (146)
UBE2D2
Tbio
Novelty:  0.00603877
p_int:  0.999949844
p_ni:  0.000050156
Score:  0.783
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  0.99985218
p_ni:  0.00014782
Score:  0.567
Data Source:  BioPlex,STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
p_int:  0.999418489
p_ni:  0.000581511
Score:  0.568
Data Source:  BioPlex,STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
p_int:  0.999345682
p_ni:  0.000654318
Score:  0.582
Data Source:  BioPlex,STRINGDB
UBE2E2
Tbio
Novelty:  0.02752227
p_int:  0.99867488
p_ni:  0.00132512
Score:  0.545
Data Source:  BioPlex,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.993905061
p_ni:  0.006094939
Score:  0.151
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.972081773
p_ni:  0.027918227
Score:  0.522
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.927531954
p_ni:  0.072468046
Score:  0.167
Data Source:  BioPlex,STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.902285357
p_ni:  0.097714643
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.890117887
p_ni:  0.109882113
Score:  0.166
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
8
10
96.1
uric acid measurement
1
2
2
95.5
waist-hip ratio
1
6
6
91.8
urate measurement
2
2
3
89.8
BMI-adjusted waist circumference
1
3
3
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
96.1
uric acid measurement
2
95.5
waist-hip ratio
6
91.8
urate measurement
3
89.8
BMI-adjusted waist circumference
3
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase, ubiquitin aldehyde binding 1
VGNC:6538
742797
Mouse
MGI:2147616
107260
Rat
RGD:1311329
293705
Dog
OTU deubiquitinase, ubiquitin aldehyde binding 1
VGNC:49784
100855636
Horse
OTU deubiquitinase, ubiquitin aldehyde binding 1
VGNC:21086
100054829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase, ubiquitin aldehyde binding 1
Mouse
Rat
Dog
OTU deubiquitinase, ubiquitin aldehyde binding 1
Horse
OTU deubiquitinase, ubiquitin aldehyde binding 1
Publication Statistics
PubMed Score 209.92
PubMed score by year
PubTator Score 31.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title