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Tbio
THOC1
THO complex subunit 1

Protein Summary
Description
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261600
  • ENSP00000261600
  • ENSG00000079134

Symbol
  • HPR1
  • P84
  • HPR1
  • P84N5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
transcription factor binding site profile
0.94
histone modification site profile
0.91
transcription factor
0.69
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.72   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.72   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
72.5
triglyceride measurement
2
2
2
37.3
coenzyme Q10 measurement
1
1
1
24.5
red blood cell distribution width
2
1
2
13.1
age at menarche
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
72.5
triglyceride measurement
2
37.3
coenzyme Q10 measurement
1
24.5
red blood cell distribution width
2
13.1
age at menarche
1
5.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THO complex 1
VGNC:5211
455324
Macaque
THO complex 1
697954
Mouse
MGI:1919668
225160
Dog
THO complex 1
VGNC:47348
490529
Horse
THO complex 1
VGNC:24082
100051155
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THO complex 1
Macaque
THO complex 1
Mouse
Dog
THO complex 1
Horse
THO complex 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96FV9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (26)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (161)
1 – 10 of 161
THOC7
Tbio
Novelty:  0.16971494
p_int:  0.999999771
p_ni:  2.29e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC3
Tbio
Novelty:  0.04716962
p_int:  0.99999842
p_ni:  0.00000158
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC5
Tbio
Novelty:  0.04618391
p_int:  0.999996454
p_ni:  0.000003546
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC2
Tbio
Novelty:  0.02886456
p_int:  0.999986235
p_ni:  0.000013765
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC6
Tbio
Novelty:  0.0744541
p_int:  0.998862307
p_ni:  0.001137692
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.98376673
p_ni:  0.01623327
Score:  0.318
Data Source:  BioPlex,STRINGDB
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.965616965
p_ni:  0.034383035
Data Source:  BioPlex
SARNP
Tbio
Novelty:  0.00987312
p_int:  0.807206957
p_ni:  0.192793043
Score:  0.983
Data Source:  BioPlex,STRINGDB
DDX39B
Tbio
Family:  Enzyme
Novelty:  0.012548
Score:  0.998
Data Source:  STRINGDB
ALYREF
Tbio
Novelty:  0.00523802
Score:  0.995
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.72

PubMed score by year
PubTator Score  117.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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