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Tbio
ASIC4
Acid-sensing ion channel 4

Protein Summary
Description
Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347842
  • ENSP00000326627
  • ENSG00000072182
  • ENST00000358078
  • ENSP00000350786

Symbol
  • ACCN4
  • ACCN4
  • BNAC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
cell type or tissue
0.68
transcription factor
0.64
molecular function
0.6
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
66
vital capacity
1
1
1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
66
vital capacity
1
29.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit family member 4
VGNC:96
743548
Macaque
acid sensing ion channel subunit family member 4
703972
Mouse
MGI:2652846
241118
Rat
RGD:621068
63882
Dog
acid sensing ion channel subunit family member 4
VGNC:38180
488537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit family member 4
Macaque
acid sensing ion channel subunit family member 4
Mouse
Rat
Dog
acid sensing ion channel subunit family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96FT7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (58)
1 – 10 of 58
HSPA14
Tbio
Novelty: 0.01714625
p_int: 0.999927489
p_ni: 0.000072511
Data Source: BioPlex
TMEM8A
Tdark
Novelty: 0.15724279
p_int: 0.998990201
p_ni: 0.000993213
p_wrong: 0.000016586
Score: 0.247
Data Source: BioPlex,STRINGDB
ADCY3
Tbio
Family: Enzyme
Novelty: 0.00260265
p_int: 0.998913445
p_ni: 0.001086553
p_wrong: 2e-9
Data Source: BioPlex
TMEM231
Tbio
Novelty: 0.17100188
p_int: 0.998730447
p_ni: 0.001269549
p_wrong: 5e-9
Data Source: BioPlex
CNNM1
Tdark
Novelty: 0.11053515
p_int: 0.998714938
p_ni: 0.001285059
p_wrong: 3e-9
Data Source: BioPlex
ITPRIP
Tdark
Novelty: 0.27051709
p_int: 0.99747607
p_ni: 0.00252393
Data Source: BioPlex
ABCA3
Tbio
Family: Transporter
Novelty: 0.00376503
p_int: 0.996057836
p_ni: 0.003942164
Data Source: BioPlex
LRP12
Tbio
Novelty: 0.11426952
p_int: 0.995775642
p_ni: 0.004223886
p_wrong: 4.72e-7
Data Source: BioPlex
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
p_int: 0.995680473
p_ni: 0.004280796
p_wrong: 0.000038731
Score: 0.215
Data Source: BioPlex,STRINGDB
CLPTM1
Tbio
Novelty: 0.06426049
p_int: 0.995432518
p_ni: 0.004567482
Score: 0.186
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.98

PubMed score by year
PubTator Score  8

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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