Tbio S100A16 Protein S100-A16

Protein Summary

Description

Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity).

Uniprot Accession IDs

• Q96FQ6
• A8K439
• D3DV52
• Q5RHS6

Gene Name

• S100A16

Ensembl ID

• ENST00000368703
• ENSP00000357692
• ENSG00000188643
• ENST00000368704
• ENSP00000357693
• ENST00000368705
• ENSP00000357694
• ENST00000368706
• ENSP00000357695

Symbol

• S100F
• AAG13
• S100F
• DT1P1A7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor perturbation	0.84
interacting protein	0.75
protein domain	0.73
cellular component	0.7

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein S100-a16

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a16

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0