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Tdark
KIF12
Kinesin-like protein KIF12

Protein Summary
Description
This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000468460
  • ENSP00000473459
  • ENSG00000136883
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.73
tissue sample
0.67
cellular component
0.59
cell line
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, knee
3
2
0
1.1
81.9
Knee pain
1
2
2
41.3
1
1
0
1.1
25.6
osteoarthritis, hip, osteoarthritis, knee
1
1
0
1.1
17.9
birth weight
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, knee
0
1.1
81.9
Knee pain
2
41.3
0
1.1
25.6
osteoarthritis, hip, osteoarthritis, knee
0
1.1
17.9
birth weight
1
11.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 12
VGNC:4773
464678
Macaque
kinesin family member 12
704313
Mouse
MGI:1098232
16552
Rat
RGD:1308487
313254
Dog
kinesin family member 12
VGNC:42380
481686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 12
Macaque
kinesin family member 12
Mouse
Rat
Dog
kinesin family member 12
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
MMADHC
Tbio
Novelty: 0.02299238
p_int: 0.839419242
p_ni: 0.000305521
p_wrong: 0.160275237
Score: 0.455
Data Source: BioPlex,STRINGDB
KIFAP3
Tbio
Novelty: 0.01902437
Score: 0.951
Data Source: STRINGDB
RACGAP1
Tbio
Family: Enzyme
Novelty: 0.01197099
Score: 0.933
Data Source: STRINGDB
KLC1
Tbio
Novelty: 0.00653484
Score: 0.922
Data Source: STRINGDB
KIFC1
Tchem
Novelty: 0.00982095
Score: 0.921
Data Source: STRINGDB
ZW10
Tbio
Novelty: 0.01680538
Score: 0.92
Data Source: STRINGDB
KIF2A
Tbio
Novelty: 0.01463006
Score: 0.919
Data Source: STRINGDB
KIFC2
Tbio
Novelty: 0.10989267
Score: 0.919
Data Source: STRINGDB
CENPE
Tchem
Novelty: 0.00458125
Score: 0.918
Data Source: STRINGDB
KIF21A
Tbio
Novelty: 0.01535562
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.55

PubMed score by year
PubTator Score  3.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer