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Tdark
CPNE2
Copine-2

Protein Summary
Description
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties. Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290776
  • ENSP00000290776
  • ENSG00000140848
  • ENST00000535318
  • ENSP00000439018
  • ENST00000565874
  • ENSP00000456042

Symbol
  • CPN2
  • COPN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.87
transcription factor binding site profile
0.75
histone modification site profile
0.74
transcription factor
0.7
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
23
25
99.1
apolipoprotein A 1 measurement
2
17
17
97.9
sleep duration
2
5
7
94.6
lymphocyte percentage of leukocytes
2
2
2
88.3
lymphocyte count
3
1
3
80.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
25
99.1
apolipoprotein A 1 measurement
17
97.9
sleep duration
7
94.6
lymphocyte percentage of leukocytes
2
88.3
lymphocyte count
3
80.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
copine 2
VGNC:8974
454111
Macaque
copine 2
703557
Mouse
MGI:2387578
234577
Rat
RGD:1586036
498972
Dog
copine 2
VGNC:39561
478115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
copine 2
Macaque
copine 2
Mouse
Rat
Dog
copine 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96FN4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (54)
1 – 10 of 54
HIP1
Tbio
Novelty:  0.03790722
p_int:  0.999999979
p_ni:  1.6e-8
p_wrong:  5e-9
Data Source:  BioPlex
RABEP2
Tbio
Family:  Enzyme
Novelty:  0.18180682
p_int:  0.999999827
p_ni:  1.73e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
USP24
Tbio
Family:  Enzyme
Novelty:  0.07281326
p_int:  0.999999529
p_ni:  4.71e-7
Score:  0.151
Data Source:  BioPlex,STRINGDB
AFDN
Tbio
Novelty:  0.00372947
p_int:  0.999998577
p_ni:  0.000001423
Data Source:  BioPlex
DNM1L
Tchem
Novelty:  0.00151314
p_int:  0.999997296
p_ni:  0.000002704
Score:  0.159
Data Source:  BioPlex,STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.999996296
p_ni:  0.000003688
p_wrong:  1.6e-8
Data Source:  BioPlex
NEK1
Tchem
Family:  Kinase
Novelty:  0.0164923
p_int:  0.999989789
p_ni:  0.000010211
Data Source:  BioPlex
PIBF1
Tbio
Novelty:  0.0454209
p_int:  0.999989447
p_ni:  0.000010553
Data Source:  BioPlex
TXLNG
Tbio
Novelty:  0.08274423
p_int:  0.999961283
p_ni:  0.000038717
Data Source:  BioPlex
EBF3
Tbio
Family:  TF
Novelty:  0.00311905
p_int:  0.999937357
p_ni:  0.000062606
p_wrong:  3.7e-8
Score:  0.16
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.43

PubMed score by year
PubTator Score  0.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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