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Tbio
PGAP3
Post-GPI attachment to proteins factor 3

Protein Summary
Description
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable). This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300658
  • ENSP00000300658
  • ENSG00000161395
  • ENST00000378011
  • ENSP00000367250
  • ENST00000429199
  • ENSP00000415765

Symbol
  • CAB2
  • PERLD1
  • CAB2
  • PERLD1
  • PP1498
  • hCOS16
  • AGLA546
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
disease perturbation
0.83
cellular component
0.68
transcription factor binding site profile
0.66
cell line
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.1   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.1   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
2
70
mathematical ability
1
1
1
63.6
smoking behaviour measurement
1
1
1
61.7
1
1
0
1.1
50.6
age at menopause
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
70
mathematical ability
1
63.6
smoking behaviour measurement
1
61.7
0
1.1
50.6
age at menopause
1
31.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
post-GPI attachment to proteins 3
VGNC:9512
454635
Macaque
post-GPI attachment to proteins 3
697699
Mouse
MGI:2444461
320655
Rat
RGD:1592386
688174
Dog
post-GPI attachment to proteins 3
VGNC:44454
491022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
post-GPI attachment to proteins 3
Macaque
post-GPI attachment to proteins 3
Mouse
Rat
Dog
post-GPI attachment to proteins 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96FM1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (55)
1 – 10 of 55
TBRG4
Tbio
Novelty: 0.03556613
p_int: 0.977309223
p_ni: 0.022690777
Score: 0.519
Data Source: BioPlex,STRINGDB
PGAP2
Tbio
Novelty: 0.06145169
Score: 0.942
Data Source: STRINGDB
MIEN1
Tbio
Novelty: 0.02381294
Score: 0.913
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.886
Data Source: STRINGDB
PIGO
Tbio
Family: Enzyme
Novelty: 0.05949164
Score: 0.876
Data Source: STRINGDB
PIGV
Tbio
Family: Enzyme
Novelty: 0.05672936
Score: 0.87
Data Source: STRINGDB
PGAP1
Tbio
Family: Enzyme
Novelty: 0.04642526
Score: 0.862
Data Source: STRINGDB
STARD3
Tbio
Novelty: 0.01540936
Score: 0.842
Data Source: STRINGDB
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
Score: 0.837
Data Source: STRINGDB
PIGW
Tbio
Novelty: 0.0245774
Score: 0.811
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.10

PubMed score by year
PubTator Score  12.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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