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Tchem
SLC47A1
Multidrug and toxin extrusion protein 1

Protein Summary
Description
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270570
  • ENSP00000270570
  • ENSG00000142494
  • ENST00000395585
  • ENSP00000378951

Symbol
  • MATE1
  • MATE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
microRNA
0.77
molecular function
0.67
histone modification site profile
0.66
PubMedID
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.95   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.95   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Approved Drugs (11)
1 – 10 of 11
imatinib
chemical structure image
ondansetron
chemical structure image
mitoxantrone
chemical structure image
pyrimethamine
chemical structure image
chlorhexidine
chemical structure image
cimetidine
chemical structure image
ritonavir
chemical structure image
gabexate
chemical structure image
pentamidine
chemical structure image
famotidine
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
6
7
9.5
94
lymphocyte count
3
3
3
83.6
creatinine measurement
4
3
4
77.2
monocyte count
1
1
1
35
1
1
0
2.7
34.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
9.5
94
lymphocyte count
3
83.6
creatinine measurement
4
77.2
monocyte count
1
35
0
2.7
34.4
Pathways (3)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Protein-Protein Interactions (112)
1 – 10 of 112
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.999741681
p_ni: 0.000258319
Data Source: BioPlex
SLC22A2
Tchem
Family: Transporter
Novelty: 0.00439263
p_int: 0.998612746
p_ni: 0.001374937
p_wrong: 0.000012317
Score: 0.871
Data Source: BioPlex,STRINGDB
GPR21
Tdark
Family: GPCR
Novelty: 0.90865557
p_int: 0.996784469
p_ni: 0.003214968
p_wrong: 5.63e-7
Data Source: BioPlex
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.996549841
p_ni: 0.003446467
p_wrong: 0.000003692
Data Source: BioPlex
ZACN
Tchem
Family: IC
Novelty: 0.21891621
p_int: 0.996017462
p_ni: 0.003980314
p_wrong: 0.000002224
Data Source: BioPlex
PTH1R
Tclin
Family: GPCR
Novelty: 0.00413989
p_int: 0.995070058
p_ni: 0.00440582
p_wrong: 0.000524122
Data Source: BioPlex
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.990358784
p_ni: 0.009641156
p_wrong: 6e-8
Score: 0.216
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.987564809
p_ni: 0.012435142
p_wrong: 4.9e-8
Data Source: BioPlex
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.982435127
p_ni: 0.015799167
p_wrong: 0.001765706
Data Source: BioPlex
HTR3C
Tchem
Family: IC
Novelty: 0.112097
p_int: 0.981819672
p_ni: 0.01348029
p_wrong: 0.004700038
Data Source: BioPlex
Publication Statistics
PubMed Score  196.95

PubMed score by year
PubTator Score  92.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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