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Tbio
DYNLL2
Dynein light chain 2, cytoplasmic

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000579991
  • ENSP00000477310
  • ENSG00000264364

Symbol
  • DLC2
  • Dlc2
  • DNCL1B
  • RSPH22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.93
disease perturbation
0.83
protein complex
0.78
virus perturbation
0.76
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of BMF and translocation to mitochondria
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of BMF and translocation to mitochondria
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (366)
1 – 10 of 366
DNAL4
Tdark
Novelty: 0.2970297
p_int: 0.999986543
p_ni: 0.000013457
p_wrong: 1e-9
Score: 0.615
Data Source: BioPlex,STRINGDB
LRFN4
Tbio
Novelty: 0.15441176
p_int: 0.997454968
p_ni: 0.002545032
Score: 0.217
Data Source: BioPlex,STRINGDB
DYNLL1
Tbio
Novelty: 0.00134262
Score: 0.997
Data Source: Reactome,STRINGDB
DYNC1H1
Tbio
Novelty: 0.01357869
Score: 0.992
Data Source: Reactome,STRINGDB
DYNC1I1
Tbio
Novelty: 0.13478098
Score: 0.991
Data Source: Reactome,STRINGDB
DYNC1I2
Tbio
Novelty: 0.00464346
Score: 0.99
Data Source: Reactome,STRINGDB
WDR34
Tbio
Novelty: 0.09255525
Score: 0.985
Data Source: STRINGDB
TCTE3
Tdark
Novelty: 0.1998141
Score: 0.976
Data Source: STRINGDB
WDR60
Tbio
Novelty: 0.19220529
Score: 0.974
Data Source: STRINGDB
DYNLRB2
Tbio
Novelty: 0.19701072
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.67

PubMed score by year
PubTator Score  13.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer