Tbio STAMBPL1 AMSH-like protease

Protein Summary

Description

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.

Uniprot Accession IDs

• Q96FJ0
• B3KPA7
• Q5T9N4
• Q5T9N9
• Q7Z420
• Q9P2H4
• AMSH-LP

Gene Name

• STAMBPL1

Ensembl ID

• ENST00000371924
• ENSP00000360992
• ENSG00000138134
• ENST00000371926
• ENSP00000360994
• ENST00000371927
• ENSP00000360995

Symbol

• AMSHLP
• KIAA1373
• AMSH-FP
• AMSH-LP
• ALMalpha
• bA399O19.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.79
trait	0.75
interacting protein	0.74
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Amsh-like Protease

Protein / ... / Metalloprotease / Amsh-like Protease

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Amsh-like Protease

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.16   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.16   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0