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Tbio
STAMBPL1
AMSH-like protease

Protein Summary
Description
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371924
  • ENSP00000360992
  • ENSG00000138134
  • ENST00000371926
  • ENSP00000360994
  • ENST00000371927
  • ENSP00000360995

Symbol
  • AMSHLP
  • KIAA1373
  • AMSH-FP
  • AMSH-LP
  • ALMalpha
  • bA399O19.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.79
trait
0.75
interacting protein
0.74
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.64   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.64   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor superfamily member 6 measurement
1
1
1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor superfamily member 6 measurement
1
39.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (311)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Metalloprotease DUBs
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Metalloprotease DUBs
Post-translational protein modification
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (118)
1 – 10 of 118
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.999999932
p_ni: 6.8e-8
Score: 0.541
Data Source: BioPlex,STRINGDB
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.999999686
p_ni: 3.13e-7
p_wrong: 1e-9
Score: 0.69
Data Source: BioPlex,STRINGDB
PIK3C2A
Tchem
Family: Kinase
Novelty: 0.0002219
p_int: 0.999998986
p_ni: 0.000001014
Score: 0.795
Data Source: BioPlex,STRINGDB
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.999998363
p_ni: 0.000001637
Score: 0.33
Data Source: BioPlex,STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
p_int: 0.999989347
p_ni: 0.000010652
Score: 0.595
Data Source: BioPlex,STRINGDB
GTSE1
Tbio
Family: Enzyme
Novelty: 0.0460569
p_int: 0.999829871
p_ni: 0.000170129
Score: 0.377
Data Source: BioPlex,STRINGDB
BMP2K
Tchem
Family: Kinase
Novelty: 0.10145601
p_int: 0.999695276
p_ni: 0.000304723
Score: 0.698
Data Source: BioPlex,STRINGDB
PICALM
Tbio
Novelty: 0.00800832
p_int: 0.999529058
p_ni: 0.000470942
Score: 0.826
Data Source: BioPlex,STRINGDB
SMAP2
Tbio
Novelty: 0.70006863
p_int: 0.997762935
p_ni: 0.002063869
p_wrong: 0.000173196
Score: 0.304
Data Source: BioPlex,STRINGDB
ZNF106
Tbio
Novelty: 0.17021565
p_int: 0.994643507
p_ni: 0.004909688
p_wrong: 0.000446805
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.64

PubMed score by year
PubTator Score  2.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer