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Tbio
NEIL1
Endonuclease 8-like 1

Protein Summary
Description
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355059
  • ENSP00000347170
  • ENSG00000140398
  • ENST00000564784
  • ENSP00000457352
  • ENST00000569035
  • ENSP00000455730

Symbol
  • FPG1
  • NEI1
  • hFPG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
virus perturbation
0.68
biological term
0.65
phenotype
0.6
cell type or tissue
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.18   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.18   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nei like DNA glycosylase 1
VGNC:7389
467829
Macaque
nei like DNA glycosylase 1
705484
Mouse
MGI:1920024
72774
Rat
RGD:1306077
367090
Dog
nei like DNA glycosylase 1
VGNC:43726
611615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nei like DNA glycosylase 1
Macaque
nei like DNA glycosylase 1
Mouse
Rat
Dog
nei like DNA glycosylase 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96FI4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (63)
1 – 10 of 63
NEIL2
Tbio
Family: Enzyme
Novelty: 0.01124634
Score: 0.991
Data Source: STRINGDB
OGG1
Tbio
Family: Enzyme
Novelty: 0.00074509
Score: 0.99
Data Source: Reactome,STRINGDB
XRCC1
Tbio
Novelty: 0.00084203
Score: 0.98
Data Source: Reactome,STRINGDB
LIG3
Tbio
Family: Enzyme
Novelty: 0.00809038
Score: 0.976
Data Source: Reactome,STRINGDB
POLB
Tchem
Family: Enzyme
Novelty: 0.00145102
Score: 0.973
Data Source: Reactome,STRINGDB
PNKP
Tbio
Family: Enzyme
Novelty: 0.01038571
Score: 0.966
Data Source: Reactome,STRINGDB
NTHL1
Tbio
Family: Enzyme
Novelty: 0.00769394
Score: 0.904
Data Source: STRINGDB
NEIL3
Tbio
Family: Enzyme
Novelty: 0.02068317
Score: 0.885
Data Source: STRINGDB
FEN1
Tchem
Family: Enzyme
Novelty: 0.00082515
Score: 0.835
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.795
Data Source: STRINGDB
Publication Statistics
PubMed Score  164.18

PubMed score by year
PubTator Score  114.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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