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Tbio
CDCA5
Sororin

Protein Summary
Description
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275517
  • ENSP00000275517
  • ENSG00000146670

Symbol
  • SORORIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
histone modification site profile
0.88
transcription factor binding site profile
0.88
kinase perturbation
0.84
PubMedID
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.87   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.87   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (259)
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.999987008
p_ni:  0.000012992
Score:  0.993
Data Source:  BioPlex,STRINGDB
STAG2
Tbio
Novelty:  0.00430441
p_int:  0.999427535
p_ni:  0.000572465
Score:  0.985
Data Source:  BioPlex,STRINGDB
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.876416819
p_ni:  0.123583181
Score:  0.163
Data Source:  BioPlex,STRINGDB
SMC3
Tbio
Novelty:  0.00474377
p_int:  0.871550176
p_ni:  0.128449824
Score:  0.997
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.994
Data Source:  Reactome,STRINGDB
AURKB
Tchem
Family:  Kinase
Novelty:  0.00100972
Score:  0.993
Data Source:  STRINGDB
CDCA8
Tbio
Novelty:  0.01448513
Score:  0.993
Data Source:  STRINGDB
SGO1
Tbio
Novelty:  0.01115849
Score:  0.993
Data Source:  STRINGDB
WAPL
Tbio
Novelty:  0.01598061
Score:  0.992
Data Source:  Reactome,STRINGDB
BIRC5
Tchem
Novelty:  0.00332112
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Establishment of Sister Chromatid Cohesion
Reactome
M Phase
Reactome
Mitotic Anaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Establishment of Sister Chromatid Cohesion
M Phase
Mitotic Anaphase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
2
2
87.4
uric acid measurement
1
1
1
69
high density lipoprotein cholesterol measurement
1
1
1
48.5
1
1
0
1.9
13.9
platelet crit
1
1
1
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
87.4
uric acid measurement
1
69
high density lipoprotein cholesterol measurement
1
48.5
0
1.9
13.9
platelet crit
1
13.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 5
VGNC:11291
451310
Macaque
cell division cycle associated 5
721998
Mouse
MGI:1915099
67849
Rat
RGD:1560863
684771
Dog
cell division cycle associated 5
VGNC:39015
612071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 5
Macaque
cell division cycle associated 5
Mouse
Rat
Dog
cell division cycle associated 5
Publication Statistics
PubMed Score 53.87
PubMed score by year
PubTator Score 26.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title