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Tbio
PIK3IP1
Phosphoinositide-3-kinase-interacting protein 1

Protein Summary
Description
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215912
  • ENSP00000215912
  • ENSG00000100100
  • ENST00000402249
  • ENSP00000385204
  • ENST00000441972
  • ENSP00000415608

Symbol
  • HGFL
  • HGFL
  • TrIP
  • hHGFL(S)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
cell type or tissue
0.72
small molecule perturbation
0.68
transcription factor
0.68
microRNA
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.34   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.34   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (19)
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Name
Explore in Pharos
Explore in Source
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Protein-Protein Interactions (28)
1 – 10 of 28
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.999953049
p_ni: 0.000046951
Data Source: BioPlex
FAM114A2
Tdark
Novelty: 0.40545319
p_int: 0.997912969
p_ni: 0.002080088
p_wrong: 0.000006944
Data Source: BioPlex
PODXL
Tbio
Novelty: 0.00306913
p_int: 0.991254178
p_ni: 0.004310597
p_wrong: 0.004435226
Data Source: BioPlex
TFRC
Tbio
Novelty: 0.00025984
p_int: 0.947729309
p_ni: 0.052270691
Data Source: BioPlex
IPO7
Tbio
Novelty: 0.01319011
p_int: 0.938763355
p_ni: 0.061236645
Data Source: BioPlex
GOLGB1
Tbio
Novelty: 0.00943584
p_int: 0.888535064
p_ni: 0.111464936
Data Source: BioPlex
SAAL1
Tdark
Novelty: 0.33089811
p_int: 0.829475421
p_ni: 0.170524544
p_wrong: 3.5e-8
Data Source: BioPlex
SRPRA
Tbio
Novelty: 0.01248718
p_int: 0.750926451
p_ni: 0.249073548
Data Source: BioPlex
TRAK2
Tbio
Novelty: 0.04192075
Score: 0.569
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.569
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.34

PubMed score by year
PubTator Score  9.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer