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Tbio
LINGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Protein Classes
Protein Summary
Description
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355300
  • ENSP00000347451
  • ENSG00000169783
  • ENST00000561030
  • ENSP00000453853

Symbol
  • LERN1
  • LRRN6A
  • LERN1
  • MRT64
  • LRRN6A
  • UNQ201
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.85
small molecule perturbation
0.61
tissue sample
0.61
protein complex
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.55   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 396   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.55   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 396   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
4
98.4
mathematical ability
2
2
2
94.2
neuroticism measurement
6
6
4
5.8
90.5
body mass index
2
1
2
89.2
wellbeing measurement
3
4
4
87.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
98.4
mathematical ability
2
94.2
neuroticism measurement
4
5.8
90.5
body mass index
2
89.2
wellbeing measurement
4
87.1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Death Receptor Signalling
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Reactome
p75NTR regulates axonogenesis
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Death Receptor Signalling
Signal Transduction
p75 NTR receptor-mediated signalling
p75NTR regulates axonogenesis
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (74)
1 – 10 of 74
LINGO2
Tbio
Novelty: 0.06112205
p_int: 1
Score: 0.688
Data Source: BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
p_int: 0.999427342
p_ni: 0.000559681
p_wrong: 0.000012977
Score: 0.158
Data Source: BioPlex,STRINGDB
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.997975214
p_ni: 0.001844452
p_wrong: 0.000180334
Data Source: BioPlex
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.997248287
p_ni: 0.002751711
p_wrong: 3e-9
Score: 0.215
Data Source: BioPlex,STRINGDB
LMAN2L
Tbio
Novelty: 0.04364985
p_int: 0.996592427
p_ni: 0.003407573
Data Source: BioPlex
MSMB
Tbio
Novelty: 0.00241546
p_int: 0.992107713
p_ni: 0.007861048
p_wrong: 0.000031239
Data Source: BioPlex
CCDC185
Tdark
Novelty: 12.6996857
p_int: 0.986418935
p_ni: 0.013580004
p_wrong: 0.000001061
Score: 0.379
Data Source: BioPlex,STRINGDB
LY86
Tbio
Novelty: 0.00314575
p_int: 0.981596736
p_ni: 0.003925472
p_wrong: 0.014477792
Score: 0.26
Data Source: BioPlex,STRINGDB
NRROS
Tbio
Novelty: 0.08976002
p_int: 0.977146955
p_ni: 0.022851985
p_wrong: 0.000001061
Data Source: BioPlex
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.976517399
p_ni: 0.02338279
p_wrong: 0.000099811
Data Source: BioPlex
Publication Statistics
PubMed Score  148.55

PubMed score by year
PubTator Score  85.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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