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Tbio
LINGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Protein Summary
Description
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355300
  • ENSP00000347451
  • ENSG00000169783
  • ENST00000561030
  • ENSP00000453853

Symbol
  • LERN1
  • LRRN6A
  • LERN1
  • MRT64
  • LRRN6A
  • UNQ201
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.85
small molecule perturbation
0.61
tissue sample
0.61
protein complex
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.76   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 396   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.76   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 396   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
LINGO2
Tbio
Novelty:  0.06112205
p_int:  1
Score:  0.688
Data Source:  BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
p_int:  0.999427342
p_ni:  0.000559681
p_wrong:  0.000012977
Score:  0.158
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.997975214
p_ni:  0.001844452
p_wrong:  0.000180334
Data Source:  BioPlex
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.997248287
p_ni:  0.002751711
p_wrong:  3e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.996592427
p_ni:  0.003407573
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.992107713
p_ni:  0.007861048
p_wrong:  0.000031239
Data Source:  BioPlex
CCDC185
Tdark
Novelty:  12.6996857
p_int:  0.986418935
p_ni:  0.013580004
p_wrong:  0.000001061
Score:  0.379
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.981596736
p_ni:  0.003925472
p_wrong:  0.014477792
Score:  0.26
Data Source:  BioPlex,STRINGDB
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.977146955
p_ni:  0.022851985
p_wrong:  0.000001061
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.976517399
p_ni:  0.02338279
p_wrong:  0.000099811
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Death Receptor Signalling
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Reactome
p75NTR regulates axonogenesis
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Death Receptor Signalling
Signal Transduction
p75 NTR receptor-mediated signalling
p75NTR regulates axonogenesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
4
90
3
2
1
1.1
79.4
mathematical ability
2
2
2
76.7
household income
1
3
3
71.8
neuroticism measurement
6
6
4
5.8
69.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
90
1
1.1
79.4
mathematical ability
2
76.7
household income
3
71.8
neuroticism measurement
4
5.8
69.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and Ig domain containing 1
VGNC:1924
453764
Macaque
leucine rich repeat and Ig domain containing 1
714985
Mouse
MGI:1915522
235402
Rat
RGD:1308668
315691
Dog
leucine rich repeat and Ig domain containing 1
VGNC:42688
487660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and Ig domain containing 1
Macaque
leucine rich repeat and Ig domain containing 1
Mouse
Rat
Dog
leucine rich repeat and Ig domain containing 1
Publication Statistics
PubMed Score 153.76
PubMed score by year
PubTator Score 85.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title