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Tbio
PELI1
E3 ubiquitin-protein ligase pellino homolog 1

Protein Summary
Description
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358912
  • ENSP00000351789
  • ENSG00000197329

Symbol
  • PRISM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
biological process
0.94
transcription factor binding site profile
0.77
microRNA
0.75
gene perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.12   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.12   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
MDM4
Tchem
Novelty:  0.00321558
p_int:  0.999999608
p_ni:  1.14e-7
p_wrong:  2.78e-7
Score:  0.624
Data Source:  BioPlex,STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.987
Data Source:  Reactome,STRINGDB
IRAK4
Tchem
Family:  Kinase
Novelty:  0.00344058
Score:  0.971
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.964
Data Source:  Reactome,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.946
Data Source:  STRINGDB
UBE2V1
Tbio
Novelty:  0.01642178
Score:  0.945
Data Source:  Reactome,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.943
Data Source:  Reactome,STRINGDB
TAB2
Tbio
Family:  Enzyme
Novelty:  0.00635786
Score:  0.939
Data Source:  STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
Score:  0.939
Data Source:  STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (152)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IRAK1 recruits IKK complex
Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
3
2
3
47.5
intelligence
1
2
0
5.8
36.5
neuroticism measurement
1
1
1
8.5
depressive symptom measurement
1
1
1
8.3
self reported educational attainment
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
3
47.5
intelligence
0
5.8
36.5
neuroticism measurement
1
8.5
depressive symptom measurement
1
8.3
self reported educational attainment
1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pellino E3 ubiquitin protein ligase 1
VGNC:333
746407
Mouse
MGI:1914495
67245
Rat
RGD:1311199
305549
Dog
pellino E3 ubiquitin protein ligase 1
VGNC:44414
481388
Horse
pellino E3 ubiquitin protein ligase 1
VGNC:21305
100051401
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pellino E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
pellino E3 ubiquitin protein ligase 1
Horse
pellino E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 25.12
PubMed score by year
PubTator Score 18.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title