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Tbio
EDC3
Enhancer of mRNA-decapping protein 3

Protein Summary
Description
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315127
  • ENSP00000320503
  • ENSG00000179151
  • ENST00000426797
  • ENSP00000401343
  • ENST00000568176
  • ENSP00000455580
  • ENST00000647659
  • ENSP00000497737

Symbol
  • LSM16
  • YJDC
  • YJEFN2
  • YJDC
  • LSM16
  • MRT50
  • YJEFN2
  • hYjeF_N2-15q23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
hub protein
0.88
kinase perturbation
0.84
microRNA
0.77
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
DCP1B
Tdark
Novelty:  0.36605365
p_int:  0.999996974
p_ni:  0.000003026
Score:  0.998
Data Source:  BioPlex,STRINGDB
PNLIPRP2
Tbio
Family:  Enzyme
p_int:  0.999946526
p_ni:  0.000053474
Data Source:  BioPlex
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.999785765
p_ni:  0.000214235
Score:  0.999
Data Source:  BioPlex,STRINGDB
PIM1
Tchem
Family:  Kinase
Novelty:  0.0049837
p_int:  0.999778636
p_ni:  0.000221364
Score:  0.871
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999610022
p_ni:  0.000389978
Data Source:  BioPlex
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.999524084
p_ni:  0.000475916
Data Source:  BioPlex
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.999228836
p_ni:  0.000771164
Score:  0.685
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.995586446
p_ni:  0.004413554
Data Source:  BioPlex
DCP1A
Tbio
Novelty:  0.02038933
p_int:  0.984475769
p_ni:  0.015524231
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 5' to 3' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 5' to 3' exoribonuclease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption measurement
4
2
4
89
cups of coffee per day measurement
2
2
3
88.5
caffeine metabolite measurement
2
3
0
8.3
86.8
urinary albumin to creatinine ratio
4
2
4
81.9
diastolic blood pressure
4
2
4
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption measurement
4
89
cups of coffee per day measurement
3
88.5
caffeine metabolite measurement
0
8.3
86.8
urinary albumin to creatinine ratio
4
81.9
diastolic blood pressure
4
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of mRNA decapping 3
VGNC:11860
453743
Macaque
enhancer of mRNA decapping 3
709182
Mouse
MGI:2142951
353190
Rat
RGD:1306898
315708
Dog
enhancer of mRNA decapping 3
VGNC:40192
487647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of mRNA decapping 3
Macaque
enhancer of mRNA decapping 3
Mouse
Rat
Dog
enhancer of mRNA decapping 3
Publication Statistics
PubMed Score 51.27
PubMed score by year
PubTator Score 9.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text