EDC3
Enhancer of mRNA-decapping protein 3
Protein Summary
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]
- ENST00000315127
- ENSP00000320503
- ENSG00000179151
- ENST00000426797
- ENSP00000401343
- ENST00000568176
- ENSP00000455580
- ENST00000647659
- ENSP00000497737
- LSM16
- YJDC
- YJEFN2
- YJDC
- LSM16
- MRT50
- YJEFN2
- hYjeF_N2-15q23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
hub protein | 0.88 | ||
kinase perturbation | 0.84 | ||
microRNA | 0.77 | ||
transcription factor binding site profile | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.42 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.42 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0