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Tbio
EDC3
Enhancer of mRNA-decapping protein 3

Protein Summary
Description
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315127
  • ENSP00000320503
  • ENSG00000179151
  • ENST00000426797
  • ENSP00000401343
  • ENST00000568176
  • ENSP00000455580
  • ENST00000647659
  • ENSP00000497737

Symbol
  • LSM16
  • YJDC
  • YJEFN2
  • YJDC
  • LSM16
  • MRT50
  • YJEFN2
  • hYjeF_N2-15q23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
hub protein
0.88
kinase perturbation
0.84
microRNA
0.77
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.98   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.98   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 5' to 3' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 5' to 3' exoribonuclease
Protein-Protein Interactions (121)
1 – 10 of 121
DDX6
Tbio
Family: Enzyme
Novelty: 0.01443731
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
DCP1B
Tdark
Novelty: 0.54634146
p_int: 0.999996974
p_ni: 0.000003026
Score: 0.998
Data Source: BioPlex,STRINGDB
PNLIPRP2
Tbio
Family: Enzyme
p_int: 0.999946526
p_ni: 0.000053474
Data Source: BioPlex
DCP2
Tbio
Family: Enzyme
Novelty: 0.00984421
p_int: 0.999785765
p_ni: 0.000214235
Score: 0.999
Data Source: BioPlex,STRINGDB
PIM1
Tchem
Family: Kinase
Novelty: 0.00108904
p_int: 0.999778636
p_ni: 0.000221364
Score: 0.871
Data Source: BioPlex,STRINGDB
USP4
Tbio
Family: Enzyme
Novelty: 0.00872265
p_int: 0.999610022
p_ni: 0.000389978
Data Source: BioPlex
GADD45GIP1
Tbio
Novelty: 0.04694836
p_int: 0.999524084
p_ni: 0.000475916
Data Source: BioPlex
BAG4
Tbio
Novelty: 0.03955483
p_int: 0.999228836
p_ni: 0.000771164
Score: 0.685
Data Source: BioPlex,STRINGDB
LPXN
Tbio
Novelty: 0.00609819
p_int: 0.995586446
p_ni: 0.004413554
Data Source: BioPlex
DCP1A
Tbio
Novelty: 0.02114877
p_int: 0.984475769
p_ni: 0.015524231
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.98

PubMed score by year
PubTator Score  9.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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