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Tclin
IL17RA
Interleukin-17 receptor A

Protein Summary
Description
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low af ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319363
  • ENSP00000320936
  • ENSG00000177663
  • ENST00000612619
  • ENSP00000479970

Symbol
  • IL17R
  • CD217
  • IL17R
  • IMD51
  • CANDF5
  • CDw217
  • IL-17RA
  • hIL-17R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell line
0.74
kinase perturbation
0.71
disease perturbation
0.68
small molecule perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.15   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 654   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.15   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
brodalumab
no chemical structure image available
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
88.3
eosinophil count
2
4
5
87
monocyte percentage of leukocytes
2
4
6
78.5
monocyte count
1
3
3
77.1
leukocyte count
2
5
5
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
88.3
eosinophil count
5
87
monocyte percentage of leukocytes
6
78.5
monocyte count
3
77.1
leukocyte count
5
71.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor A
VGNC:5981
458629
Macaque
interleukin 17 receptor A
709005
Mouse
MGI:107399
16172
Rat
RGD:1306559
312679
Dog
interleukin 17 receptor A
VGNC:41946
486759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor A
Macaque
interleukin 17 receptor A
Mouse
Rat
Dog
interleukin 17 receptor A
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Signaling by Interleukins
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (169)
1 – 10 of 169
KIAA0586
Tbio
Novelty: 0.0346398
p_int: 0.99988138
p_ni: 0.000089736
p_wrong: 0.000028885
Data Source: BioPlex
RPS6KA3
Tchem
Family: Kinase
Novelty: 0.00221219
p_int: 0.999871635
p_ni: 0.000128365
Score: 0.298
Data Source: BioPlex,STRINGDB
RPS6KA2
Tchem
Family: Kinase
Novelty: 0.00409407
p_int: 0.999792957
p_ni: 0.000206692
p_wrong: 3.52e-7
Data Source: BioPlex
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
p_int: 0.999671837
p_ni: 0.000314338
p_wrong: 0.000013825
Score: 0.169
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.99960197
p_ni: 0.000398023
p_wrong: 7e-9
Data Source: BioPlex
DDX11
Tbio
Family: Enzyme
Novelty: 0.02282234
p_int: 0.999252171
p_ni: 0.000747824
p_wrong: 5e-9
Data Source: BioPlex
SIK2
Tchem
Family: Kinase
Novelty: 0.01957886
p_int: 0.999075653
p_ni: 0.000924321
p_wrong: 2.6e-8
Data Source: BioPlex
PLCH1
Tbio
Family: Enzyme
Novelty: 0.11128204
p_int: 0.99877359
p_ni: 0.001154291
p_wrong: 0.00007212
Data Source: BioPlex
PLEKHA5
Tbio
Novelty: 0.11245799
p_int: 0.998496403
p_ni: 0.001362669
p_wrong: 0.000140928
Score: 0.185
Data Source: BioPlex,STRINGDB
ZNF318
Tbio
Novelty: 0.03072403
p_int: 0.998449367
p_ni: 0.001550629
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  217.15

PubMed score by year
PubTator Score  115.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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