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Tclin
IL17RA
Interleukin-17 receptor A

Protein Summary
Description
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low af ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319363
  • ENSP00000320936
  • ENSG00000177663
  • ENST00000612619
  • ENSP00000479970

Symbol
  • IL17R
  • CD217
  • IL17R
  • IMD51
  • CANDF5
  • CDw217
  • IL-17RA
  • hIL-17R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell line
0.74
kinase perturbation
0.71
disease perturbation
0.68
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.91   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 654   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.91   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
brodalumab
no chemical structure image available
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Signaling by Interleukins
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (169)
1 – 10 of 169
KIAA0586
Tbio
Novelty: 0.04074584
p_int: 0.99988138
p_ni: 0.000089736
p_wrong: 0.000028885
Data Source: BioPlex
RPS6KA3
Tchem
Family: Kinase
Novelty: 0.00292563
p_int: 0.999871635
p_ni: 0.000128365
Score: 0.298
Data Source: BioPlex,STRINGDB
RPS6KA2
Tchem
Family: Kinase
Novelty: 0.00638792
p_int: 0.999792957
p_ni: 0.000206692
p_wrong: 3.52e-7
Data Source: BioPlex
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00250734
p_int: 0.999671837
p_ni: 0.000314338
p_wrong: 0.000013825
Score: 0.169
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.05351568
p_int: 0.99960197
p_ni: 0.000398023
p_wrong: 7e-9
Data Source: BioPlex
DDX11
Tbio
Family: Enzyme
Novelty: 0.02910864
p_int: 0.999252171
p_ni: 0.000747824
p_wrong: 5e-9
Data Source: BioPlex
SIK2
Tchem
Family: Kinase
Novelty: 0.02679057
p_int: 0.999075653
p_ni: 0.000924321
p_wrong: 2.6e-8
Data Source: BioPlex
PLCH1
Tbio
Family: Enzyme
Novelty: 0.20668236
p_int: 0.99877359
p_ni: 0.001154291
p_wrong: 0.00007212
Data Source: BioPlex
PLEKHA5
Tbio
Novelty: 0.19241048
p_int: 0.998496403
p_ni: 0.001362669
p_wrong: 0.000140928
Score: 0.185
Data Source: BioPlex,STRINGDB
ZNF318
Tbio
Novelty: 0.04010695
p_int: 0.998449367
p_ni: 0.001550629
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  143.91

PubMed score by year
PubTator Score  115.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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