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Tbio
TRIM11
E3 ubiquitin-protein ligase TRIM11

Protein Summary
Description
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284551
  • ENSP00000284551
  • ENSG00000154370
  • ENST00000366699
  • ENSP00000355660

Symbol
  • RNF92
  • BIA1
  • RNF92
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.98
disease perturbation
0.79
biological process
0.71
cell line
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.78   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.78   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
1
1
0
5.5
55
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
0
5.5
55
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 11
VGNC:53210
457799
Macaque
tripartite motif containing 11
694150
Mouse
MGI:2137355
94091
Rat
RGD:1305448
360534
Dog
tripartite motif containing 11
VGNC:47804
482205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 11
Macaque
tripartite motif containing 11
Mouse
Rat
Dog
tripartite motif containing 11
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (334)
1 – 10 of 334
CAMKK1
Tchem
Family: Kinase
Novelty: 0.06355265
p_int: 0.999999473
p_ni: 5.27e-7
Data Source: BioPlex
RLF
Tdark
Novelty: 0.73853259
p_int: 0.999996721
p_ni: 0.000003279
Score: 0.255
Data Source: BioPlex,STRINGDB
USF1
Tbio
Family: TF
Novelty: 0.00136587
p_int: 0.999987143
p_ni: 0.000009519
p_wrong: 0.000003339
Data Source: BioPlex
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.2377644
p_int: 0.999983982
p_ni: 0.000016018
Data Source: BioPlex
ZSCAN26
Tdark
Novelty: 0.21423827
p_int: 0.999983473
p_ni: 0.000016523
p_wrong: 4e-9
Score: 0.235
Data Source: BioPlex,STRINGDB
TRIM44
Tbio
Novelty: 0.00483553
p_int: 0.99997901
p_ni: 0.00002099
Score: 0.337
Data Source: BioPlex,STRINGDB
RPS6KA3
Tchem
Family: Kinase
Novelty: 0.00221219
p_int: 0.999953011
p_ni: 0.000046989
Data Source: BioPlex
KDM3B
Tbio
Family: Epigenetic
Novelty: 0.05322289
p_int: 0.999949875
p_ni: 0.000050125
Data Source: BioPlex
RABGAP1
Tbio
Family: Enzyme
Novelty: 0.14270101
p_int: 0.99990841
p_ni: 0.00009159
Data Source: BioPlex
TEPSIN
Tdark
Novelty: 0.48775142
p_int: 0.999902437
p_ni: 0.000097563
Data Source: BioPlex
Publication Statistics
PubMed Score  54.78

PubMed score by year
PubTator Score  15.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer