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Tbio
ALG14
UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Protein Summary
Description
May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370205
  • ENSP00000359224
  • ENSG00000172339

Symbol
  • CMS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.75
cell type or tissue
0.67
kinase perturbation
0.66
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Disease
Diseases associated with N-glycosylation of proteins
Protein-Protein Interactions (74)
1 – 10 of 74
FADS3
Tbio
Family: Enzyme
Novelty: 0.05947668
p_int: 0.999999362
p_ni: 6.37e-7
Score: 0.221
Data Source: BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty: 0.00061543
p_int: 0.999982563
p_ni: 0.000013755
p_wrong: 0.000003682
Data Source: BioPlex
TSPAN1
Tbio
Novelty: 0.02017548
p_int: 0.999959376
p_ni: 0.000036202
p_wrong: 0.000004422
Data Source: BioPlex
TSPAN31
Tdark
Novelty: 0.19615058
p_int: 0.999959376
p_ni: 0.000036202
p_wrong: 0.000004422
Data Source: BioPlex
HAUS7
Tbio
Novelty: 1.2
p_int: 0.999130052
p_ni: 0.000007863
p_wrong: 0.000862085
Score: 0.21
Data Source: BioPlex,STRINGDB
LRTM2
Tdark
Novelty: 2.4
p_int: 0.998311953
p_ni: 0.000034978
p_wrong: 0.001653069
Data Source: BioPlex
ALG13
Tbio
Family: Enzyme
Novelty: 0.07584422
Score: 0.997
Data Source: Reactome,STRINGDB
DPAGT1
Tbio
Family: Enzyme
Novelty: 0.00248803
Score: 0.996
Data Source: STRINGDB
ALG1
Tbio
Family: Enzyme
Novelty: 0.01683144
Score: 0.978
Data Source: STRINGDB
ALG5
Tbio
Family: Enzyme
Novelty: 0.08726413
Score: 0.867
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.11

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer