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Tbio
ALG14
UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Protein Summary
Description
May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370205
  • ENSP00000359224
  • ENSG00000172339

Symbol
  • CMS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.75
cell type or tissue
0.67
kinase perturbation
0.66
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
2
3
3
86.3
cigarettes per day measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
3
86.3
cigarettes per day measurement
1
15.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALG14, UDP-N-acetylglucosaminyltransferase subunit
VGNC:76
457040
Mouse
MGI:1914039
66789
Rat
RGD:1312003
362031
Dog
ALG14, UDP-N-acetylglucosaminyltransferase subunit
VGNC:37796
612241
Horse
ALG14, UDP-N-acetylglucosaminyltransferase subunit
VGNC:15247
100058111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALG14, UDP-N-acetylglucosaminyltransferase subunit
Mouse
Rat
Dog
ALG14, UDP-N-acetylglucosaminyltransferase subunit
Horse
ALG14, UDP-N-acetylglucosaminyltransferase subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96F25-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Disease
Diseases associated with N-glycosylation of proteins
Protein-Protein Interactions (74)
1 – 10 of 74
FADS3
Tbio
Family:  Enzyme
Novelty:  0.02899077
p_int:  0.999999362
p_ni:  6.37e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999982563
p_ni:  0.000013755
p_wrong:  0.000003682
Data Source:  BioPlex
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.999959376
p_ni:  0.000036202
p_wrong:  0.000004422
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.999959376
p_ni:  0.000036202
p_wrong:  0.000004422
Data Source:  BioPlex
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.999130052
p_ni:  0.000007863
p_wrong:  0.000862085
Score:  0.21
Data Source:  BioPlex,STRINGDB
LRTM2
Tdark
Novelty:  1.14285986
p_int:  0.998311953
p_ni:  0.000034978
p_wrong:  0.001653069
Data Source:  BioPlex
ALG13
Tbio
Family:  Enzyme
Novelty:  0.04054611
Score:  0.997
Data Source:  Reactome,STRINGDB
DPAGT1
Tbio
Family:  Enzyme
Novelty:  0.00869839
Score:  0.996
Data Source:  STRINGDB
ALG1
Tbio
Family:  Enzyme
Novelty:  0.012911
Score:  0.978
Data Source:  STRINGDB
ALG5
Tbio
Family:  Enzyme
Novelty:  0.04358658
Score:  0.867
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.01

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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