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Tbio
NRBF2
Nuclear receptor-binding factor 2

Protein Summary
Description
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277746
  • ENSP00000277746
  • ENSG00000148572
  • ENST00000435510
  • ENSP00000397502

Symbol
  • COPR
  • COPR
  • COPR1
  • COPR2
  • NRBF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
drug perturbation
0.87
transcription factor binding site profile
0.86
cell type or tissue
0.67
cell line
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.17   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.17   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
5
11
94
alkaline phosphatase measurement
1
1
1
88.4
reticulocyte measurement
2
2
2
85.5
neutrophil count
2
1
2
84.9
mean corpuscular hemoglobin concentration
1
1
1
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
94
alkaline phosphatase measurement
1
88.4
reticulocyte measurement
2
85.5
neutrophil count
2
84.9
mean corpuscular hemoglobin concentration
1
83.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor binding factor 2
VGNC:4968
450488
Macaque
nuclear receptor binding factor 2
697756
Mouse
MGI:1354950
641340
Rat
RGD:61937
58839
Dog
nuclear receptor binding factor 2
VGNC:43960
479220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor binding factor 2
Macaque
nuclear receptor binding factor 2
Mouse
Rat
Dog
nuclear receptor binding factor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96F24-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (23)
1 – 10 of 23
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
p_int:  0.999999998
p_ni:  2e-9
Score:  0.961
Data Source:  BioPlex,STRINGDB
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.999999969
p_ni:  2.6e-8
p_wrong:  6e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
p_int:  0.999999967
p_ni:  3.1e-8
p_wrong:  2e-9
Score:  0.974
Data Source:  BioPlex,STRINGDB
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
p_int:  0.999999445
p_ni:  5.55e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999997971
p_ni:  0.000002029
Data Source:  BioPlex
SOGA3
Tdark
Novelty:  2.17187131
p_int:  0.999997169
p_ni:  0.00000283
p_wrong:  1e-9
Score:  0.516
Data Source:  BioPlex,STRINGDB
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.999896333
p_ni:  0.000103653
p_wrong:  1.4e-8
Score:  0.327
Data Source:  BioPlex,STRINGDB
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
p_int:  0.999488369
p_ni:  0.000511631
Score:  0.93
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999062931
p_ni:  0.000598782
p_wrong:  0.000338287
Data Source:  BioPlex
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.975080764
p_ni:  0.024915585
p_wrong:  0.000003652
Score:  0.211
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  48.17

PubMed score by year
PubTator Score  15.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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